Schisandrin

Research use only, not for human use.

Schisandrin is a compound with anti-asthmatic, anti-cancer, and anti-inflammatory effects.

Schizandrin is a bio-active isolate of Schisandra chinensis that has been found to act as an agonist of the adiponectin receptor 2 (AdipoR2).(In Vitro):Schisandrin (10-100 μM; pretreated for 2 h) inhibits LPS-stimulated NO production, iNOS protein and mRNA expression in a dose-dependent manner in RAW 264.7 cells.Schisandrin (25-100 μM; pretreated for 2 h) inhibits prostaglandin E2 production, COX-2 protein and mRNA expression in LPS-stimulated RAW 264.7 macrophages.Schisandrin inhibits the SK-HEP-1, SNU-638, and T47D cells proliferation, with IC50s of 42.0, 53.1, and 40.0 μM, respectively.Schisandrin (10-60 μM; 48 h) enhances Doxorubicin -induced apoptosis and selectively reverses MCF-7/DOX resistance.(In Vivo):Schisandrin (10-100 mg/kg; a single i.p.) inhibits acetic acid-induced peritoneal vascular permeability and reduces the carrageenan-induced paw edema of mice.Schisandrin (1-10 mg/kg; a single p.o.) significantly reverses the Scopolamine-induced impairment of spatial memory and passive avoidance response, and enhances tremors induced by Oxotremorine in rats.

Schisandrin (10-100 μM; pretreated for 2 h) inhibits LPS-stimulated NO production, iNOS protein and mRNA expression in a dose-dependent manner in RAW 264.7 cells.Schisandrin (25-100 μM; pretreated for 2 h) inhibits prostaglandin E2 production, COX-2 protein and mRNA expression in LPS-stimulated RAW 264.7 macrophages.Schisandrin inhibits the SK-HEP-1, SNU-638, andT47D cells proliferation, with IC50s of 42.0, 53.1, and 40.0 μM, respectively.Schisandrin (10-60 μM; 48 h) enhances Doxorubicin -induced apoptosis and selectively reverses MCF-7/DOX resistance. Cell Viability Assay Cell Line:RAW 264.7 macrophages Concentration:12.5, 25, 50, 100 μM Incubation Time:Pretreated for 2 h and then incubated with LPS (1 μg/mL) for 18 h Result:Markedly decreased iNOS protein expression a dose-dependent manner.Significantly inhibited COX-2 protein expression.

Schisandrin (10-100 mg/kg; a single i.p.) inhibits acetic acid-induced peritoneal vascular permeability and reduces the carrageenan-induced paw edema of mice.Schisandrin (1-10 mg/kg; a single p.o.) significantly reverses the Scopolamine-induced impairment of spatial memory and passive avoidance response, and enhances tremors induced by Oxotremorine in rats. Animal Model:Male ICR mice (4-weeks) were treated with λ-carrageenan by intraperitoneal injection into the right hind paw Dosage:100, 200 mg/kg Administration:A single i.p.Result:Inhibited paw edema by 33.43 % (100 mg/kg) and 57.38 % (200 mg/kg) at 3 h.

Schizandrin | Gomisins | Magnolia Vine | Omija

Others

Other Targets

Others

Inflammation/Immunology

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7432-28-2

432.51

C24H32O7

>98% (HPLC)

DMSO : 1 mg/mL 2.31 mM

c12c(c3c(C[C@@H]([C@](C1)(O)C)C)cc(c(c3OC)OC)OC)c(c(c(c2)OC)OC)OC

(6S,7S)-1,2,3,10,11,12-hexamethoxy-6,7-dimethyl-5,6,7,8-tetrahydrodibenzo[a,c][8]annulen-6-ol

(-20℃)

With Ice Pack

≥ 2 years