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MRS 2578
CAS No. 711019-86-2
MRS 2578( MRS-2578 | MRS2578 | MRS 2578 )
Catalog No. M19028 CAS No. 711019-86-2
MRS2578, an effective P2Y6 receptor antagonist with IC50 of 37 nM, shows insignificant inhibition at P2Y1, P2Y2, P2Y4, and P2Y11 receptors.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 1 mL x 10 mM in DMSO | 39 | In Stock |
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| 5MG | 36 | In Stock |
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| 10MG | 46 | In Stock |
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| 25MG | 100 | In Stock |
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| 50MG | 166 | In Stock |
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| 100MG | 267 | In Stock |
|
| 200MG | 402 | In Stock |
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| 500MG | Get Quote | In Stock |
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| 1G | Get Quote | In Stock |
|
Biological Information
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Product NameMRS 2578
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NoteResearch use only, not for human use.
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Brief DescriptionMRS2578, an effective P2Y6 receptor antagonist with IC50 of 37 nM, shows insignificant inhibition at P2Y1, P2Y2, P2Y4, and P2Y11 receptors.
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DescriptionMRS-2578 is a selective antagonist of P2Y6 nucleotide receptors (IC50 values are 37 and 98 nM at human and rat P2Y6 receptors respectively). Activation of P2Y6 receptor amplifies mucosal adenosine triphosphate release underlying bladder overactivity in patients with benign prostatic hyperplasia. Therefore, selective P2Y6 receptor blockade as a novel therapeutic strategy is potentially useful to control persistent storage symptoms in obstructed patients.
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In VitroMRS2578 (1 μM) completely blocks the protection by UDP undergoing TNFα-induced apoptosis in 1321N1 astrocytoma cells. ?MRS 2578 (10 μM) completely abolishes TNF-α induced NF-κB reporter activity in HMEC-1 cells. MRS 2578 (10 μM) significant reduces TNF-α–induced proinflammatory gene expression in HMEC-1 cells.
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In VivoMRS2578 (3 mg/kg; i.p.; for 3 days) significantly suppresses pressure overload-induced collagen deposition without affecting cardiomyocyte hypertrophy after transverse aortic constriction (TAC). Animal Model:6-week-old male C57BL/6J mice Dosage:3 mg/kg Administration:Intraperitoneal injection; daily for 3 days after TAC Result:Significantly suppressed pressure overload-induced collagen deposition.
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SynonymsMRS-2578 | MRS2578 | MRS 2578
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PathwayOthers
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TargetOther Targets
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RecptorP2Y6
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Research AreaCardiovascular Disease
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Indication——
Chemical Information
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CAS Number711019-86-2
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Formula Weight472.67
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Molecular FormulaC20H20N6S4
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Purity>98% (HPLC)
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SolubilityDMSO : ≥ 80 mg/mL; 169.25 mM
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SMILESS=C=NC1=CC=CC(NC(=S)NCCCCNC(=S)NC2=CC(=CC=C2)N=C=S)=C1
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Chemical Name1,1'-(butane-1,4-diyl)bis(3-(3-isothiocyanatophenyl)thiourea)
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1. Mamedova LK, et al. Biochem Pharmacol, 2004, 67(9), 1763-1770.
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