Buprofezin

Research use only, not for human use.

Buprofezin is an insecticide used for control of insect pests such as mealybugs, leafhoppers and whitefly on vegetable crops.

Buprofezin is an insecticide used for control of insect pests such as mealybugs, leafhoppers and whitefly on vegetable crops.

RT-PCRCell Line:HepG2 cellsConcentration:3, 10, 30 μMIncubation Time:24 hResult:Significantly increased lactate dehydrogenase B (LDHB) levels when at 30 μM, and slightly increased 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 3 (PFKFB3).Decreased ATP levels in a concentration-dependent manner to 91.3, 87.9 and 67.2% of the levels in the vehicle control under treatment with 3, 10 and 30 μM buprofezin, respectively.Significantly increased the lactate levels.Immunofluorescence Cell Line:HepG2 cells Concentration:3, 10, 30 μM Incubation Time:24 h Result:Significantly inhibited the activity of Complex IV to 82.2, 69.2 and 63.4% of the vehicle control levels following buprofezin treatment at 3, 10 and 30 μM, respectively.Cell Viability Assay Cell Line:HepG2 cells Concentration:3, 10, 30 μM Incubation Time:24 h Result:Significantly increased the intracellular ROS levels in a concentrate-independent manner, and decreased mtDNA contents.

Animal Model:Male C57BL/6 mice (6 to 8-week-old).Dosage:46.3, 139, 417 mg/kg Administration:Oral administration; single Result:Tended to elevate the MDA level in all organs, and the most significant concentration-dependent increases were observed in the liver and brain.Exhibited the highest concentrations in the liver (35.84%) followed by the brain (23.58%), stomach (21.94%) and kidney (18.64%), while the levels in the mouse spleen and heart were below the limit of detection.

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Others

Other Targets

Others

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69327-76-0

305.44

C16H23N3OS

>98% (HPLC)

In Vitro:?DMSO : 100 mg/mL (327.40 mM)

CC(C)N1\C(SCN(C1=O)c1ccccc1)=N\C(C)(C)C

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(-20℃)

With Ice Pack

≥ 2 years