Traumatic Acid

Research use only, not for human use.

Traumatic Acid is a product of the hydroperoxide lyase pathway in plants. Potential as a wound healing agent that stimulates cell division near a wound site to form a protective callus.

Traumatic Acid is a product of the hydroperoxide lyase pathway in plants. Potential as a wound healing agent that stimulates cell division near a wound site to form a protective callus.

Traumatic Acid (0.1, 1 μM; 5 days) significantly increases cell number in fibroblasts.Traumatic Acid (0.1, 1 μM; 5 days) increases content of GPX activity and reduced glutathione, as well as decreases membrane phospholipid peroxidation in fibroblasts.Traumatic Acid (0.1, 1 μM; 5 days) enhances the production and secretion of medium collagen in medium of fibroblasts.Traumatic Acid (100, 200, 400, 600 μM; 48 h) significantly decreases live cell number, especially after 48h treatment at 100μM and 200μM in MCF-7 cells.Traumatic Acid (50-600 μM; 24, 48 h) causes dose-and time-dependent reduction in cell viability and induces apoptosis in MCF-7 cells.Traumatic Acid (50-200 μM; 24, 48 h) results in an oxidative damage of protein in MCF-7 cells.Traumatic Acid (100, 200 μM; 24, 48 h) efficiently enhances oxidative stress level in MCF-7 cells.Cell Proliferation AssayCell Line:Fibroblasts Concentration:0.1, 1 μM Incubation Time:5 days Result:Caused a significant increase in cell number, especially on day 1 at a concentration of 1 μM.Increased cell number of 133 % and 118 % compared to the untreated control cells for concentrations of 1 and 0.1 μM, respectively.Cell Viability Assay Cell Line: Fibroblasts Concentration:0.1, 1 μM Incubation Time:5 days Result:Increased total protein content of 183 % and 90% compared to the control at concentrations of 1 and 0.1 μM on day 1.Increased collagen content of 72 % at 0.1 μM (on the day 3) and of 51 % at 1 μM (on the day 1) compared to the control.Increased GPX activity by 111 % and 97 % at concentrations of 1 and 0.1 μM compared to the control.Increased content of reduced glutathione of 86 % and 80% at 0.1 and 1 μM, respectively.Decreased membrane phospholipid peroxidation.Cell Viability Assay Cell Line:MCF-7 cells Concentration:100, 200, 400, 600 μM Incubation Time:48 h Result:Decreasd live cell number of about 76% at 100 μM concentration.Cell Viability Assay Cell Line:MCF-7 cells Concentration:50-200 μMIncubation Time:24, 48 h Result: Increased thiol group content of 167% at 100μM and 24 h.Cell Viability Assay Cell Line:MCF-7 cells Concentration:100, 200 μM Incubation Time:24, 48 h Result:Increased the amount of ROS.Apoptosis Analysis Cell Line:MCF-7 cells Concentration:50-600 μM Incubation Time:24, 48 h Result:Increased level of apoptosis in a time- and dose-dependent manner.

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Others

Other Targets

Others

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6402-36-4

228.28

C12H20O4

>98% (HPLC)

In Vitro:?DMSO : 250 mg/mL (1095.15 mM)

C(CCCCC(=O)O)CCC/C=C/C(=O)O

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(-20℃)

With Ice Pack

≥ 2 years