Berberine hydrogen sulphate

Research use only, not for human use.

Berberine sulfate, an alkaloid extracted from several plants, possesses antimicrobial activity against a wide variety of microorganisms including Gram-positive and Gram-negative bacteria, fungi, and protozoa.

Berberine sulfate, an alkaloid extracted from several plants, possesses antimicrobial activity against a wide variety of microorganisms including Gram-positive and Gram-negative bacteria, fungi, and protozoa.

Cell Proliferation Assay Cell Line:Four colorectal carcinoma cell lines LoVo, HCT116, SW480, and HT-29 Concentration:1.25, 2.5, 5, 10, 20, 40, 80, and 160 μM Incubation Time:72 hours Result:Inhibited the proliferation of four cell lines. The IC50 ranged from 40.8±4.1 μM (LoVo) to 98.6±2.9 μM (HCT116).Cell Proliferation AssayCell Line:Colorectal carcinoma cell lines LoVo Concentration:1.25, 2.5, 5, 10, 20, 40, 80, and 160 μM Incubation Time:24, 48, 72 hours Result:Induced a time- and dose-dependent inhibition of cell growth. By 72 h, 160.0 μM induced 71.1±1.9 % growth inhibitions in LoVo cells.Cell Cycle Analysis Cell Line:LoVo cells Concentration:0, 10, 20, 40, or 80 μM Incubation Time:24 hours Result:Exposure to 40.0 μM induced G2/M-phase cell cycle arrest, an increase in the G2/M-phase population and a progressive decline in the G1 population.Western Blot Analysis Cell Line:LoVo cells Concentration:10, 20, 40, or 80 μM Incubation Time:24 hours Result:Suppressed cyclin B1, cdc2 and cdc25c protein expression.

Animal Model:5-week-old BALB/c nu/nu mice with human colorectal adenocarcinoma LoVo xenograftsDosage:10, 30, or 50 mg/kg/day Administration:Gastrointestinal gavage; for 10 consecutive days Result:Showed inhibitory rates of 33.1% and 45.3% at doses of 30 and 50 mg/kg/day.

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GPCR/G Protein

Antibacterial

Antibacterial

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633-66-9

433.43

C20H19NO8S

>98% (HPLC)

In Vitro:?H2O : 50 mg/mL (115.36 mM)

COC1=C(C2=C[N+]3=C(C=C2C=C1)C4=CC5=C(C=C4CC3)OCO5)OC.OS(=O)(=O)[O-]

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(-20℃)

With Ice Pack

≥ 2 years