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Synephrine HCl

CAS No. 5985-28-4

Synephrine HCl( Oxedrine hydrochloride )

Catalog No. M18871 CAS No. 5985-28-4

SynephrineHCl (Oxedrine, p-Synephrine) is an agonist that acts on sympathomimetic α-adrenergic receptor (AR).

Purity : >98% (HPLC)

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Biological Information

  • Product Name
    Synephrine HCl
  • Note
    Research use only, not for human use.
  • Brief Description
    SynephrineHCl (Oxedrine, p-Synephrine) is an agonist that acts on sympathomimetic α-adrenergic receptor (AR).
  • Description
    SynephrineHCl (Oxedrine, p-Synephrine) is an agonist that acts on sympathomimetic α-adrenergic receptor (AR).(In Vivo):Synephrine (1 mg/kg; oral gavage; for 8 days; PVL and BDL rats) significantly ameliorates the hyperdynamic state in both PVL and BDL rats. The portal venous pressure in PVL and BDL rats, portal tributary blood flow and cardiac index are significantly reduced, while mean arterial pressure and systemic as well as portal territory vascular resistance are enhanced by treatment of Synephrine.
  • In Vitro
    ——
  • In Vivo
    Synephrine (1 mg/kg; oral gavage; for 8 days; PVL and BDL rats) significantly ameliorates the hyperdynamic state in both PVL and BDL rats. The portal venous pressure in PVL and BDL rats, portal tributary blood flow and cardiac index are significantly reduced, while mean arterial pressure and systemic as well as portal territory vascular resistance are enhanced by treatment of Synephrine. Animal Model:Portal vein ligation (PVL) or bile duct ligation (BDL) rats Dosage:1 mg/kg per 12 hours Administration:Oral gavage; for 8 days Result:The portal venous pressure in PVL and BDL rats, portal tributary blood flow and cardiac index were significantly reduced, while mean arterial pressure and systemic as well as portal territory vascular resistance were enhanced.
  • Synonyms
    Oxedrine hydrochloride
  • Pathway
    Others
  • Target
    Other Targets
  • Recptor
    α-adrenergic receptor
  • Research Area
    Neurological Disease
  • Indication
    ——

Chemical Information

  • CAS Number
    5985-28-4
  • Formula Weight
    203.67
  • Molecular Formula
    C9H13NO2·HCl
  • Purity
    >98% (HPLC)
  • Solubility
    DMSO : ≥ 52 mg/mL; 255.31 mM
  • SMILES
    C(c1ccc(cc1)O)(CNC)O.Cl
  • Chemical Name
    ——

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1. Huang YT, et al. Jpn J Pharmacol, 2001, 85(2), 183-188.
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