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Platycodin D

CAS No. 58479-68-8

Platycodin D( —— )

Catalog No. M18847 CAS No. 58479-68-8

Platycodin D may stimulate TNF-α synthesis or inhibit degradation of TNF-α mRNA. Platycodin D (10/30 μM) suppresses prostaglandin E2 production in rat peritoneal macrophages stimulated by the protein kinase C activator 12-O-tetradecanoyl phorbol 13-acetate (TPA).

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
Size Price / USD Stock Quantity
1 mL x 10 mM in DMSO 55 In Stock
2MG 32 In Stock
5MG 49 In Stock
10MG 81 In Stock
25MG 147 In Stock
50MG 221 In Stock
100MG 341 In Stock
200MG Get Quote In Stock
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Biological Information

  • Product Name
    Platycodin D
  • Note
    Research use only, not for human use.
  • Brief Description
    Platycodin D may stimulate TNF-α synthesis or inhibit degradation of TNF-α mRNA. Platycodin D (10/30 μM) suppresses prostaglandin E2 production in rat peritoneal macrophages stimulated by the protein kinase C activator 12-O-tetradecanoyl phorbol 13-acetate (TPA).
  • Description
    Platycodin D may stimulate TNF-α synthesis or inhibit degradation of TNF-α mRNA. Platycodin D (10/30 μM) suppresses prostaglandin E2 production in rat peritoneal macrophages stimulated by the protein kinase C activator 12-O-tetradecanoyl phorbol 13-acetate (TPA). Platycodin D and D3 are useful as expectorant agents in the treatment of various airway diseases, they can increase mucin release from rat and hamster tracheal surface epithelial cell culture and also from intact rat trachea upon nebulization.
  • In Vitro
    ——
  • In Vivo
    Animal Model:Genetically obese db/db mice Dosage:5 mg/kg Administration:Oral administration; 5 mg/kg, 5 times per week for 5 weeks Result:Significantly decreased body weight gain without affecting food intake of mice. Decreased the liver tissue weight and increased the weight of brown adipose tissue (BAT).
  • Synonyms
    ——
  • Pathway
    Endocrinology/Hormones
  • Target
    AChR
  • Recptor
    PGE2
  • Research Area
    Others-Field
  • Indication
    ——

Chemical Information

  • CAS Number
    58479-68-8
  • Formula Weight
    1225.34
  • Molecular Formula
    C57H92O28
  • Purity
    >98% (HPLC)
  • Solubility
    In Vitro:?DMSO : 50 mg/mL (40.81 mM)
  • SMILES
    C1C(CC[C@@]2([C@@H](C[C@@]3([C@@]4(CC[C@H]5C([C@H]([C@H](C[C@@]5(C4CC=C3[C@H]12)C)O)O[C@@H]1O[C@@H]([C@H]([C@@H]([C@H]1O)O)O)CO)(CO)CO)C)C)O)C(=O)O[C@@H]1OC[C@@H]([C@@H]([C@H]1O[C@@H]1O[C@H]([C@@H]([C@H]([C@H]1O)O)O[C@@H]1OC[C@H]([C@@H]([C@H]1O)O[C@@H]1OC[C@@]([C@H]1O)(CO)O)O)C)O)O)(C)C
  • Chemical Name
    ——

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1. Kwon OG,ET AL. The Effects of Platycodin D, a Saponin Purified from Platycodi Radix, on Collagen-Induced DBA/1J Mouse Rheumatoid Arthritis. Evid Based Complement Alternat Med. 2014;2014:954508.
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