Bergaptol( 5-Hydroxypsoralen | 4-Hydroxybergapten )

Catalog No. M18628 CAS No. 486-60-2

COA

Datasheet

HNMR

HPLC

MSDS

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Product Name

Bergaptol
Note

Research use only, not for human use.
Brief Description

Bergaptol is a potent inhibitor of debenzylation activity of CYP3A4 enzyme.
Description

Bergaptol shows very good radical scavenging activity. Bergaptol is a potent inhibitor of debenzylation activity of CYP3A4 enzyme.
In Vitro

Western Blot Analysis Cell Line:LPS-induced RAW264.7 cells Concentration:50 μg/mL Incubation Time:24 h Result:Inhibited JNK phosphorylation and NF-κB activation.Inhibited NF-κB P65 translocation from the cytosol to nucleus.
In Vivo

Animal Model:LPS (40 μg/kg, i.c.v.)-treated miceDosage:10-40 mg/kg Administration:i.p., once a day for two week Result:Reduced LPS-induced fixation and cleavage of neuronal nuclei in the CA1 region of the hippocampus (H&E staining).Increasead the dendritic spine density of mice.Inhibited LPS-induced neuroinflammation.
Synonyms

5-Hydroxypsoralen | 4-Hydroxybergapten
Pathway

Others
Target

Other Targets
Recptor

Others
Research Area

Cancer
Indication

——

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