Dehydrocostus Lactone( Dehydrocostus Lactone | (-)-Dehydrocostus lactone. )

Catalog No. M18596 CAS No. 477-43-0

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Product Name

Dehydrocostus Lactone
Note

Research use only, not for human use.
Brief Description

Dehydrocostus Lactone is a major sesquiterpene lactone isolated from the roots of Saussurea lappa.
Description

Dehydrocostus Lactone is a natural sesquiterpene first isolated from costus root, which is used in traditional medicine. Dehydrocostus lactone, a natural sesquiterpene lactone, suppresses the biological characteristics of glioma, through inhibition of the NF-κB/COX-2 signaling pathway by targeting IKKβ. Dehydrocostus Lactone Suppresses Proliferation of Human Chronic Myeloid Leukemia Cells Through Bcr/Abl-JAK/STAT Signaling Pathways. Dehydrocostus Lactone Inhibits Proliferation, Antiapoptosis, and Invasion of Cervical Cancer Cells Through PI3K/Akt Signaling Pathway.
In Vitro

——
In Vivo

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Synonyms

Dehydrocostus Lactone | (-)-Dehydrocostus lactone.
Pathway

Others
Target

Other Targets
Recptor

Others
Research Area

Others-Field
Indication

——

CAS Number

477-43-0
Formula Weight

230.3
Molecular Formula

C15H18O2
Purity

>98% (HPLC)
Solubility

DMSO : ≥ 62.5 mg/mL; 271.39 mM
SMILES

C=C1CC[C@@H]2[C@@H]([C@@H]3[C@H]1CCC3=C)OC(=O)C2=C
Chemical Name

(3aS,6aR,9aR,9bS)-3,6,9-trimethylenedecahydroazuleno[4,5-b]furan-2(3H)-one

1. Dong GZ, et al. PhytOthers Res. 2015 May;29(5):680-6.

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