S-Isocorydine(+)

Research use only, not for human use.

S-Isocorydine(+) and its derivatives have anticancer activities.

Isocorydine is an alkaloid from root tubers of Stephania Kwangsiensis H.S. Lo.(In Vitro):Isocorydine (0-400 ug/ml; 48 hours) show a significant decrease in the IC50 for ICD and DOX, the CI values are 0.605, 0.644, 0.804, and 0.707 respectively for Huh-7, Hep-G2, SNU-449 and SNU-387.Isocorydine (0-400 ug/ml; 48 hours) abrogates DOX-induced upregulation of mesenchymal markers and the downregulation of epithelial markers in human HCC cell lines.(In Vivo):Isocorydine (intraperitoneal injection; 0.4 mg/kg; every 2 days for 2 weeks) retards the tumor growth, but the combined treatment of Doxorubicin (DOX) or ICD significantly inhibits tumor growth.

Isocorydine (0-400 ug/ml; 48 hours) show a significant decrease in the IC50 for ICD and DOX, the CI values are 0.605, 0.644, 0.804, and 0.707 respectively for Huh-7, Hep-G2, SNU-449 and SNU-387. Isocorydine (0-400 ug/ml; 48 hours)abrogates DOX-induced upregulation of mesenchymal markers and the downregulation of epithelial markers in human HCC cell lines. Cell Viability Assay Cell Line:Huh-7, Hep-G2 , SNU-387, SNU-449 cells Concentration:0-400 ug/ml Incubation Time:24 hours Result:Had a higher cytotoxicity in HCC cells in comparison to ICD or DOX alone.Western Blot Analysis Cell Line:Huh-7, Hep-G2 , SNU-387, SNU-449 cells Concentration:Incubation Time:24 hours Result:Downregulated protein levels of Claundin-1 and E-cadherin.

Isocorydine (intraperitoneal injection; 0.4 mg/kg; every 2 days for 2 weeks) retards the tumor growth, but the combined treatment of Doxorubicin (DOX) or ICD significantly inhibits tumor growth. Animal Model:Female nude mice Dosage:0.4 mg/ml Administration:Injected intraperitoneally every 2 days for 2 weeks Result:Combined treatment of isocorydine and DOX showed a promising potential to eradicate HCC.

Isocorydine | Luteanin | d-Isocorydine | NSC32979

Others

Other Targets

Others

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475-67-2

341.41

C20H23NO4

>98% (HPLC)

In Vitro:?DMSO : 20 mg/mL (58.58 mM)

CN1CCc2cc(c(c3c2[C@@H]1Cc1c3c(c(cc1)OC)O)OC)OC

(S)-1,2,10-trimethoxy-6-methyl-5,6,6a,7-tetrahydro-4H-dibenzo[de,g]quinolin-11-ol

(-20℃)

With Ice Pack

≥ 2 years