Cart
sales@molnova.com
Home - Products - GPCR/G Protein - Antibacterial - TCS-PIM-1-4a

TCS-PIM-1-4a

CAS No. 438190-29-5

TCS-PIM-1-4a( SMI-4a | SMI4a | SMI 4a | TCS PIM-1 4a. )

Catalog No. M18552 CAS No. 438190-29-5

(Z)-SMI-4a is a selective ATP-competitive Pim-1 kinase inhibitor with an IC50 of 21 nM.

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
Size Price / USD Stock Quantity
5MG 42 In Stock
10MG 59 In Stock
25MG 132 In Stock
50MG 205 In Stock
100MG 307 In Stock
200MG 463 In Stock
500MG Get Quote In Stock
1G Get Quote In Stock
Get Quotation Bulk Inquiry Add to Cart

Biological Information

  • Product Name
    TCS-PIM-1-4a
  • Note
    Research use only, not for human use.
  • Brief Description
    (Z)-SMI-4a is a selective ATP-competitive Pim-1 kinase inhibitor with an IC50 of 21 nM.
  • Description
    SMI-4a is a potent and selective Pim protein kinase inhibitor, which blocks the growth of precursor T-cell lymphoblastic leukemia/lymphoma. SMI-4a was found to induce phosphorylation of extracellular signal-related kinase1/2 (ERK1/2), and the combination of SMI-4a and a mitogen-activated protein kinase kinase 1/2 (MEK1/2) inhibitor was highly synergistic in killing pre-T-LBL cells. SMI-4a may be developed as a therapeutic strategy for the treatment of pre-T-LBL.
  • In Vitro
    Western Blot Analysis Cell Line:HEK-293T cells Concentration:0.5 μM Incubation Time:1 hour Result:Caused a dose-dependent reduction in Pim-1-induced 4E-BP1 phosphorylation, with an IC50 of approximately 125 nM.
  • In Vivo
    ——
  • Synonyms
    SMI-4a | SMI4a | SMI 4a | TCS PIM-1 4a.
  • Pathway
    GPCR/G Protein
  • Target
    Antibacterial
  • Recptor
    Pim1
  • Research Area
    Cancer
  • Indication
    ——

Chemical Information

  • CAS Number
    438190-29-5
  • Formula Weight
    273.23
  • Molecular Formula
    C11H6F3NO2S
  • Purity
    >98% (HPLC)
  • Solubility
    In Vitro:?DMSO : ≥ 100 mg/mL (365.99 mM)
  • SMILES
    c1cc(cc(c1)C(F)(F)F)/C=C\1/C(=O)NC(=O)S1
  • Chemical Name
    5-(3-(trifluoromethyl)benzylidene)thiazolidine-2,4-dione

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1. Beharry Z, et al. Mol Y Ther, 2009, 8(6), 1473-1483.
Calculator

Molecular Weight Calculator

Dilution Calculator

Molarity Calculator

molnova catalog
related products

  • Chlorothalonil

    Chlorothalonil is a broad-spectrum fungicide with high efficiency and low toxicity.

  • HA5

    HA5 has antimicrobial activity and inhibits the biofilm formation of Streptococcus mutans with an IC50 value of 6.42 μM. HA5 inhibits the production of Streptococcus mutans dextran and the level of eDNA, but it does not inhibit the growth of Streptococcus mutans.

  • Fosfomycin calcium

    Fosfomycin calcium is an antibiotics, used in urinary tract infections and intestinal infections caused by susceptible strains.

Sign In Join Free