5-methoxyflavone

Research use only, not for human use.

5-methoxyflavone is a naturally occurring, low molecular weight flavonoids compound that associated with a wide wariety of biological activities.

5-methoxyflavone is a naturally occurring, low molecular weight flavonoids compound that associated with a wide wariety of biological activities.

5-Methoxyflavone (compound 1) is identified as a candidate compound endowed with the ability to inhibit DNA pol-β in multiple and to prevent cell-cycle initiation and subsequent neuronal apoptosis in Aβ-challenged primary neuronal cultures. 5-methoxyflavone (10-30 μM) is able to significantly enhance toxicity of MMS on 92TAg cells. 5-Methoxyflavone (1 or 10 μM) significantly reduces polymerase activity on a gapped substrate. 5-Methoxyflavone (5-MF, 0-100 μg/mL) results in a time dependent reduction in the levels of antiapoptotic proteins cFLIP, Mcl-1 and an increase in the proapoptotic protein BAX. 5-MF induces both TRAIL-R1(DR4) and TRAIL-R2 (DR5) in a time-dependent manner.

5-Methoxyflavone (100, 150 mg/kg, i.p) significantly decreases the latency time to loss of righting reflex. 5-Methoxyflavone (50, 100 and 150 mg/kg, i.p) exhibits a significant and dose-dependent reduction in the spontaneous locomotor activity. 5-Methoxyflavone (50, 100 mg/kg, i.p) reduces the rearing response. 5-Methoxyflavone (100, 125 and 150 mg/kg, i.p) completely abolishesed the grooming response similar to diazepam treated animals.

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Others

Other Targets

Others

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42079-78-7

252.26

C16H12O3

>98% (HPLC)

DMSO : 125 mg/mL 495.52 mM

COc1cccc2c1c(=O)cc(o2)c1ccccc1

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(-20℃)

With Ice Pack

≥ 2 years