UK 383367( UK-383367, UK 383367, UK383367 )

Catalog No. M18461 CAS No. 348622-88-8

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Datasheet

HNMR

HPLC

MSDS

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Product Name

UK 383367
Note

Research use only, not for human use.
Brief Description

UK-383367 is a procollagen C-proteinase inhibitor with IC50 of 44 nM, has excellent selectivity over MMPs.
Description

UK-383367 is a potent and selective inhibitor of BMP-1 (procollagen C-proteinase; PCP) (IC50 = 44 nM). Bone morphogenic protein 1 (BMP1) is an enzyme responsible for the cleavage and maturation of growth factors and ECM proteins. The purpose of our study was to determine whether cultured human trabecular meshwork (TM) cells express BMP1, BMP1 expression is regulated by TGF-β2, BMP1 is biologically active, and BMP1 regulates LOX activity.
In Vitro

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In Vivo

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Synonyms

UK-383367, UK 383367, UK383367
Pathway

MAPK/ERK Signaling
Target

p38 MAPK
Recptor

Procollagen C proteinase
Research Area

Others-Field
Indication

——

CAS Number

348622-88-8
Formula Weight

324.38
Molecular Formula

C15H24N4O4
Purity

>98% (HPLC)
Solubility

In Vitro:?DMSO : 65 mg/mL (200.38 mM)
SMILES

NC(=O)C1=NOC(=N1)[C@H](CCCC1CCCCC1)CC(=O)NO
Chemical Name

(R)-5-(6-cyclohexyl-1-(hydroxyamino)-1-oxohexan-3-yl)-1,2,4-oxadiazole-3-carboxamide

1. Fish PV, et al. J Med Chem, 2007, 50(15), 3442-3456.

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