Madecassoside

Research use only, not for human use.

Madecassoside is a pentacyclic triterpene extracted from Centella asitica (L.) with anti-inflammatory, anti-oxidative and anti-aging activities.

Madecassoside is a pentacyclic triterpene extracted from Centella asitica (L.) with anti-inflammatory, anti-oxidative and anti-aging activities.

Cell Viability Assay Cell Line:HUVECs Concentration:10, 30, 100 μmol/L Incubation Time:12 h Result:Increased cell viability to 68.9% and 78.3%, with concentration of 30 and 100 μmol/L, respectively.Western Blot Analysis Cell Line:HUVECs Concentration:10, 30, 100 μmol/L Incubation Time:12 h Result:Inhibited phosphorylation in p38 MAPK.

Animal Model:Focal cerebral ischemia reperfusion injury in Sprague Dawley rats Dosage:6, 12, 24 mg/kg Administration:Intravenous injection Result:Reduced neurological deficit, infarct area, brain damage and neuronal apoptosis.Animal Model:Lipopolysaccharide-induced neurotoxicity in Sprague-Dawley rats Dosage:30-120 mg/kg for 14 days Administration:Intraperitoneal injection Result:Reduced LPS-induced cognitive impairment and imflammatory cytokine, promoted Nrf2 pathway at concentration of 120 mg/kg.

Asiaticoside A

Others

Other Targets

Others

Others-Field

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34540-22-2

975.12

C48H78O20

>98% (HPLC)

DMSO : ≥ 9.8 mg/mL; 10.05 mM

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(-20℃)

With Ice Pack

≥ 2 years