Adenosine disodium triphosphate( —— )

Catalog No. M18452 CAS No. 34369-07-8

COA

Datasheet

HNMR

HPLC

MSDS

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Product Name

Adenosine disodium triphosphate
Note

Research use only, not for human use.
Brief Description

Adenosine triphosphate (ATP) is a nucleoside triphosphate used in cells as a coenzyme often called the "molecular unit of currency" of intracellular energy transfer.
Description

Adenosine triphosphate (ATP) is a nucleoside triphosphate used in cells as a coenzyme often called the "molecular unit of currency" of intracellular energy transfer.
In Vitro

ATP disodium salt hydrate (5mM; 1 hour) co-treatment with LPS (1 μg/ml) has a synergistic effect on the activation of the NLRP3 inflammasome in HGFs.ATP disodium salt hydrate (2 mM; 0.5-24 hours) induces secretion of interleukin 1β, KC and MIP-2 from bone marrow derived macrophages (BMDMs) in vitro in a caspase-1 activation-dependent manner.?ATP disodium salt hydrate stimulats cytokine and chemokine secretion and inflammasome activation directly and indirectly induces in vitro neutrophil chemotaxis.
In Vivo

ATP disodium salt hydrate (50 mg/kg; i.p.) protects mice against bacterial infection in vivo.ATP disodium salt hydrate induces the secretion of IL1β, KC and MIP-2 and neutrophils recruitment in vivo. Animal Model:Four-week-old Kunming mice (18-22 g)Dosage:50 mg/kg Administration:Intraperitoneal injection, before bacterial (E. coli) challengeResult:Protected mice from bacterial infection.
Synonyms

——
Pathway

Others
Target

Other Targets
Recptor

Others
Research Area

——
Indication

——

CAS Number

34369-07-8
Formula Weight

551.15
Molecular Formula

C10H14N5Na2O13P3
Purity

>98% (HPLC)
Solubility

In Vitro:?H2O : 100 mg/mL
SMILES

c1nc2c(c(n1)N)ncn2C1[C@@H]([C@@H]([C@H](O1)COP(=O)(O)OP(=O)([O-])OP(=O)(O)[O-])O)O.O.[Na+].[Na+]
Chemical Name

——

1. Shan G, et al. Se Pu. 2014 Nov;32(11):1275-9.

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