CLOZAPINE N-OXIDE( Clozapine N-oxide )

Catalog No. M18447 CAS No. 34233-69-7

COA

Datasheet

HNMR

HPLC

MSDS

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Product Name

CLOZAPINE N-OXIDE
Note

Research use only, not for human use.
Brief Description

Clozapine N-oxide is a major metabolite of clozapine that can be detected in the earliest excretion time interval after clozapine administration.
Description

Clozapine N-oxide is a major metabolite of clozapine that can be detected in the earliest excretion time interval after clozapine administration. It is produced by the action of cytochrome P450 (CYP) isoforms CYP1A2 and CYP3A4, whose activities, in turn, can be affected by drugs and disease. Clozapine N-oxide is normally biologically inactive. However, it can be used in designer receptor exclusively activated by designer drugs, also known as DREADDs, technology to modulate synthetic receptors in vivo.
In Vitro

——
In Vivo

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Synonyms

Clozapine N-oxide
Pathway

Others
Target

Other Targets
Recptor

Others
Research Area

Neurological Disease
Indication

——

CAS Number

34233-69-7
Formula Weight

342.82
Molecular Formula

C18H19ClN4O
Purity

>98% (HPLC)
Solubility

DMSO : ≥ 100 mg/mL 291.70 mM; Methanol : ≥ 28.6 mg/mL 83.43 mM H2O : 1 mg/mL 2.92 mM
SMILES

Clc1ccc2Nc4ccccc4C(=Nc2c1)N3CC[N+]([O-])(C)CC3
Chemical Name

3-Chloro-6-(4-methyl-4-oxidopiperazin-4-ium-1-yl)-5H-benzo[b][1,4]benzodiazepine

1. Dain, J.G., et al. Biotransformation of clozapine in humans. Drug Metabolism and Disposition 25(5), 603-609 (1997).

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