Echinatin

Research use only, not for human use.

Echinatin disturb the mitochondrial energy transfer reactions and membrane permeability, at a low concentration cause deterioration of respiratory control and oxidative phosphorylation of isolated rat liver mitochondria.

Echinatin disturb the mitochondrial energy transfer reactions and membrane permeability, at a low concentration cause deterioration of respiratory control and oxidative phosphorylation of isolated rat liver mitochondria, inhibits DNP-ATPase activity while stimulating range latent ATPase activity. Echinatin has significant antioxidant activities, it shows strong scavenging activity toward the ABTS + radical, it also dose-dependently inhibits LPS induced reactive oxygen species (ROS) production in RAW 264.7 cells and inhibits the production of nitric oxide (NO), interleukin-6 (IL-6) and prostaglandin E2 (PGE2) in LPS-induced macrophage cells.

Western Blot Analysis Cell Line:LPS-primed BMDMs Concentration:0-40 μM Incubation Time:60 min Result:Reduced cleaved caspase-1 and production of IL-1β.Immunofluorescence Cell Line:KYSE30 and KYSE270 cells Concentration:40 μM Incubation Time:2 days Result:Induced cellular LC3 puncta accumulation.

Animal Model:LPS-induced septic shock in miceDosage:20 and 40 mg/kg Administration:i.p.Result:Inhibited LPS-induced IL-1β and TNF-α production.Reduced the proportion and the number of neutrophils in peritoneal lavage cells from mice.

Echinatin | Retrochalcone

Others

Other Targets

Free radical scavengers

Others-Field

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34221-41-5

270.28

C16H14O4

>98% (HPLC)

In Vitro:?DMSO : 125 mg/mL (462.48 mM)

COc2cc(O)ccc2/C=C/C(=O)c1ccc(O)cc1

(E)-3-(4-hydroxy-2-methoxyphenyl)-1-(4-hydroxyphenyl)prop-2-en-1-one

(-20℃)

With Ice Pack

≥ 2 years