Negletein

Research use only, not for human use.

Negletein has anti-inflammatory and immunomodulatory activities via inhibition of TNF-α, iNOS and IL-1β.

Negletein has anti-inflammatory and immunomodulatory activities via inhibition of TNF-α, iNOS and IL-1β. Negletein as a neuroprotectant enhances the action of nerve growth factor and induces neurite outgrowth in PC12 cells. Negletein shows a comparable redox-active potential, and it (50 μM, 4 h) can activate Nrf2. Negletein shows significant antimicrobial activity. Negletein has anti-hypoxia activity, it can significantly prolong the survival time of hypoxic mice.Negletein has anti- Alzheimer's disease activity, it inhibits the iron-dependent formation of ROS and also blocks the iron-induced oligomerization of amyloid beta 42 in vitro. Negletein (IC50: 3.89 +/- 0.39 microM) exhibits potent inhibitory activity against nuclear factor of activated T cells (NFAT) transcription factor.

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Negletein

Others

Other Targets

Others

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29550-13-8

284.26

C16H12O5

>98% (HPLC)

In Vitro:?DMSO : 100 mg/mL (351.79 mM)

COC1=C(C(=C2C(=C1)OC(=CC2=O)C3=CC=CC=C3)O)O

4H-1-Benzopyran-4-one, 5,6-dihydroxy-7-methoxy-2-phenyl-

(-20℃)

With Ice Pack

≥ 2 years