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TRAM-34
CAS No. 289905-88-0
TRAM-34( TRAM-34 | TRAM34 | TRAM 34 )
Catalog No. M18371 CAS No. 289905-88-0
TRAM-34(Kd=20 nM), an effective and specific inhibitor of the intermediate-conductance Ca2+-activated K+ channel (IKCa1, KCa3.1), does not block cytochrome P450.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 10MG | 39 | In Stock |
|
| 25MG | 73 | In Stock |
|
| 50MG | 133 | In Stock |
|
| 100MG | 176 | In Stock |
|
| 200MG | 228 | In Stock |
|
| 500MG | 383 | In Stock |
|
| 1G | Get Quote | In Stock |
|
Biological Information
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Product NameTRAM-34
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NoteResearch use only, not for human use.
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Brief DescriptionTRAM-34(Kd=20 nM), an effective and specific inhibitor of the intermediate-conductance Ca2+-activated K+ channel (IKCa1, KCa3.1), does not block cytochrome P450.
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DescriptionTRAM-34 is a highly selective blocker of intermediate conductance Ca2+-activated K+ channels (KCa3.1) (Kd = 20 nM). Exhibits 200-1500-fold selectivity over KV, BKCa, KCa2, Na+, CRAC and Cl- channels. Suppresses the reactivation of lymphocytes by mitogenic stimuli, and does not block cytochrome P450.
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In Vitro——
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In Vivo——
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SynonymsTRAM-34 | TRAM34 | TRAM 34
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PathwayOthers
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TargetOther Targets
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RecptorIKCa1 (KCa3.1)
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Research AreaNeurological Disease
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Indication——
Chemical Information
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CAS Number289905-88-0
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Formula Weight344.84
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Molecular FormulaC22H17ClN2
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Purity>98% (HPLC)
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SolubilityDMSO : ≥ 3.5 mg/mL; 10.15 mM
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SMILESn1(nccc1)C(c1ccccc1)(c1ccccc1)c1c(cccc1)Cl
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Chemical Name1-[(2-Chlorophenyl)diphenylmethyl]-1H-pyrazole
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1. Wulff H, et al. Design of a potent and selective inhibitor of the intermediate-conductance Ca2+-activated K+ channel, IKCa1: a potential immunosuppressant. Proc Natl Acad Sci U S A. 2000 Jul 5;97(14):8151-6.
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