Cart
sales@molnova.com
TRAM-34
CAS No. 289905-88-0
TRAM-34( TRAM-34 | TRAM34 | TRAM 34 )
Catalog No. M18371 CAS No. 289905-88-0
TRAM-34(Kd=20 nM), an effective and specific inhibitor of the intermediate-conductance Ca2+-activated K+ channel (IKCa1, KCa3.1), does not block cytochrome P450.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 1 mL x 10 mM in DMSO | 46 | In Stock |
|
| 10MG | 41 | In Stock |
|
| 25MG | 77 | In Stock |
|
| 50MG | 138 | In Stock |
|
| 100MG | 181 | In Stock |
|
| 200MG | 235 | In Stock |
|
| 500MG | 395 | In Stock |
|
| 1G | Get Quote | In Stock |
|
Biological Information
-
Product NameTRAM-34
-
NoteResearch use only, not for human use.
-
Brief DescriptionTRAM-34(Kd=20 nM), an effective and specific inhibitor of the intermediate-conductance Ca2+-activated K+ channel (IKCa1, KCa3.1), does not block cytochrome P450.
-
DescriptionTRAM-34 is a highly selective blocker of intermediate conductance Ca2+-activated K+ channels (KCa3.1) (Kd = 20 nM). Exhibits 200-1500-fold selectivity over KV, BKCa, KCa2, Na+, CRAC and Cl- channels. Suppresses the reactivation of lymphocytes by mitogenic stimuli, and does not block cytochrome P450.
-
In Vitro——
-
In Vivo——
-
SynonymsTRAM-34 | TRAM34 | TRAM 34
-
PathwayOthers
-
TargetOther Targets
-
RecptorIKCa1 (KCa3.1)
-
Research AreaNeurological Disease
-
Indication——
Chemical Information
-
CAS Number289905-88-0
-
Formula Weight344.84
-
Molecular FormulaC22H17ClN2
-
Purity>98% (HPLC)
-
SolubilityDMSO : ≥ 3.5 mg/mL; 10.15 mM
-
SMILESn1(nccc1)C(c1ccccc1)(c1ccccc1)c1c(cccc1)Cl
-
Chemical Name1-[(2-Chlorophenyl)diphenylmethyl]-1H-pyrazole
Shipping & Storage Information
-
Storage(-20℃)
-
ShippingWith Ice Pack
-
Stability≥ 2 years
Reference
1. Wulff H, et al. Design of a potent and selective inhibitor of the intermediate-conductance Ca2+-activated K+ channel, IKCa1: a potential immunosuppressant. Proc Natl Acad Sci U S A. 2000 Jul 5;97(14):8151-6.
molnova catalog
related products
-
Biotinyl tyramide
Biotinyl tyramide, a biotin derivative, is used for tyramide signal amplification, as a reagent to amplify both in situ hybridization and immunohistochemical signals protocols.
-
LY2955303
LY2955303 is an effective and selective antagonist of retinoic acid receptor gamma (RARγ, Ki = 1.09 nM).
-
BMT-124110
BMT-124110 is a selective AAK1 inhibitor (IC50: 0.9 nM) with antinociceptive activity. BMT-090605 inhibited BMP-2 induced protein kinase BIKE with IC50 of 17 nM.
