Chaetocin( Chaetocin )

Catalog No. M18357 CAS No. 28097-03-2

COA

Datasheet

HNMR

HPLC

MSDS

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Product Name

Chaetocin
Note

Research use only, not for human use.
Brief Description

Chaetocin, a natural product from Chaetomium species, is a histone methyltransferase inhibitor with IC50 of 0.8 μM, 2.5 μM and 3 μM for dSU(VAR)3-9, mouse G9a and Neurospora crassa DIM5, respectively.
Description

Chaetocin is an inducer of apoptosis in human melanoma cells, generating reactive oxygen species and the intrinsic mitochondrial pathway.
In Vitro

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In Vivo

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Synonyms

Chaetocin
Pathway

Others
Target

Other Targets
Recptor

dSU(VAR)3-9 | mouse G9a|Neurospora crassa DIM5
Research Area

Cancer
Indication

——

CAS Number

28097-03-2
Formula Weight

696.84
Molecular Formula

C30H28N6O6S4
Purity

>98% (HPLC)
Solubility

DMSO : ≥ 26 mg/mL 37.31 mM; H2O : < 0.1 mg/mL
SMILES

CN1C(=O)[C@@]23C[C@]4([C@@H](N2C(=O)[C@@]1(SS3)CO)NC5=CC=CC=C54)[C@]67C[C@]89C(=O)N([C@](C(=O)N8[C@H]6NC1=CC=CC=C71)(SS9)CO)C
Chemical Name

(3S,3'S,5aR,5aR,10bR,10'bR,11aS,11'aS)-2,2',3,3',5a,5'a,6,6'-octahydro-3,3'-bis(hydroxymethyl)-2,2'-dimethyl-[10b,10'b(11H,11'H)-bi3,11a-epidithio-11aH-pyrazino[1',2':1,5]pyrrolo[2,3-b]indole]-1,1',4,4'-tetrone