Peimine( 5α-Cevane-3β,6α,20-triol | Verticine | Dihydroisoimperialine )

Catalog No. M18278 CAS No. 23496-41-5

COA

Datasheet

HNMR

HPLC

MSDS

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Product Name

Peimine
Note

Research use only, not for human use.
Brief Description

Peimine is an inhibitor to inhibit LPS-induced production of inflammatory cytokines by blocking the MAPKs and NF-κB signaling pathway.
Description

Peimine, also known as Verticine, is a known MAPK inhibitor, as well as an inhibitor of p38, ERK and JNK phosphorylation, and NFκB activation. Peimine shows antitussive, expectorant and anti-inflammatory effects in vivo. Peimine inhibits the growth and motility of prostate cancer cells and induces apoptosis by disruption of intracellular calcium homeostasis through Ca2+ /CaMKII/JNK pathway.
In Vitro

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In Vivo

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Synonyms

5α-Cevane-3β,6α,20-triol | Verticine | Dihydroisoimperialine
Pathway

Others
Target

Other Targets
Recptor

Others
Research Area

Inflammation/Immunology
Indication

——

CAS Number

23496-41-5
Formula Weight

431.66
Molecular Formula

C27H45NO3
Purity

>98% (HPLC)
Solubility

In Vitro:?DMSO : 50 mg/mL (115.83 mM)
SMILES

CC1CCC2C(C3CCC4C(C3CN2C1)CC5C4CC(C6C5(CCC(C6)O)C)O)(C)O
Chemical Name

(3S,4aS,5S,6aS,6bS,8aS,9S,9aS,12S,15aR,15bR,16aR,16bS)-9,12,16b-trimethyltetracosahydrobenzo[4,5]indeno[1,2-h]pyrido[1,2-b]isoquinoline-3,5,9-triol