Selamectin

Research use only, not for human use.

Selamectin is a macrocyclic lactone derivative of ivermectin, an anthelmintic that potentiates glutamate- and GABA-gated chloride channel opening in nematodes.

Selamectin is a topical parasiticide and anthelminthic used on dogs and cats. It treats and prevents infections of heartworms, fleas, ear mites, sarcoptic mange (scabies), and certain types of ticks in dogs, and prevents heartworms, fleas, ear mites, hookworms, and roundworms in cats.(In Vitro):The transport of radiolabelled Selamectin through Caco-2 monolayers shows that Selamectin is P-glycoprotein (P-gp) substrates with a secretory/absorptive ratio of 4.7. Selamectin inhibits the efflux of Rh-123 from peripheral blood lymphocytes (PBL) and the concentration of inhibition is similar to that of Verapamil.(In Vivo):A single administration of 6 mg/kg topical Selamectin given every two months could effectively prevent B. malayi infection in cats. Application of topical Selamectin twice a year could block circulating microfilariae.

The transport of radiolabelled Selamectin through Caco-2 monolayers shows that Selamectin is P-glycoprotein (P-gp) substrates with a secretory/absorptive ratio of 4.7. Selamectin inhibits the efflux of Rh-123 from peripheral blood lymphocytes (PBL) and the concentration of inhibition is similar to that of Verapamil.

A single administration of 6 mg/kg topical Selamectin given every two months could effectively prevent B. malayi infection in cats. Application of topical Selamectin twice a year could block circulating microfilariae.

Selamectin | Revolution | Stronghold

Apoptosis

Caspase

Others

Others-Field

——

220119-17-5

769.96

C43H63NO11

>98% (HPLC)

DMSO : 100 mg/mL 129.88 mM

C/C/1=C\C[C@@H]2C[C@H](OC(=O)[C@H]3[C@@]4(/C(=C/C=C/[C@@H]([C@@H]1O[C@H]1C[C@H](OC)[C@@H](O)[C@H](C)O1)C)/CO[C@@H]4/C(=N\O)/C(=C3)C)O)C[C@]1(CC[C@H](C)[C@@H](C3CCCCC3)O1)O2

A name could not be generated for this structure.

(-20℃)

With Ice Pack

≥ 2 years