Gentiopicrin

Research use only, not for human use.

Gentiopicroside, a naturally occurring iridoid glycoside, extracted from Gentiana manshurica Kitag, inhibits P450 activity, with an IC50 and a Ki of 61 μM and 22.8 μM for CYP2A6.

Gentiopicrin is found in gentiana and cephalaria. It displays many biological properties, including suppressing expression of NMDA receptors in the anterior cingulate cortex, inhibiting morphine conditioned place preference, and preventing arachidonic acid and PMA-induced superoxide generation.

Gentiopicroside inhibits P450 activity, with an IC50 and a Ki of 61 μM and 8.12 μM for CYP2A6, also slightly inhibits CYP2E1 activity with an IC50 of 1.6 mM, but shows no inhibition on CYP1A2 and CYP3A4. Gentiopicroside (12.5, 25 and 50?μM) inhibits RANKL-induced osteoclast formation from mouse bone marrow macrophages (BMMs) in a dose-dependent manner, blocks the expression of osteoclast-related proteins, prevents receptor activator of nuclear factor-κB ligand (RANKL)-triggered JNK and NF-κB activation. Gentiopicroside (50?μM) also inhibits RANKL-induced bone resorption.

Gentiopicroside (20, 40, and 80 mg/kg, p.o.) significantly reduces gastric ulcerindex in mice. Gentiopicroside (20, 40, and 80 mg/kg) also ovbiously decreases the levels of HSP-70, TNF-α, IL-6, MDA and increases ncreased GSH level and SOD activity. In addition, Gentiopicroside normalizes EGF and VEGF level in mice.

O673 | O-673 | O 673 | SC-46058

Others

Other Targets

Others

Others-Field

——

20831-76-9

356.33

C16H20O9

>98% (HPLC)

DMSO : ≥ 150 mg/mL; 420.97 mM

C=C[C@H]1[C@@H](OC=C2C1=CCOC2=O)O[C@H]1[C@@H]([C@H]([C@@H]([C@H](O1)CO)O)O)O

(5R,6S)-6-(((2S,3R,4S,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)tetrahydro-2H-pyran-2-yl)oxy)-5-vinyl-5,6-dihydro-1H,3H-pyrano[3,4-c]pyran-1-one

(-20℃)

With Ice Pack

≥ 2 years