Saikosaponin C( Saikosaponin C )

Catalog No. M18225 CAS No. 20736-08-7

COA

Datasheet

HNMR

HPLC

MSDS

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Product Name

Saikosaponin C
Note

Research use only, not for human use.
Brief Description

Saikosaponin C efficiently inhibited LPS-induced apoptotic cell death via inhibition of caspase-3 activation and caspase-3-mediated-FAK degradation.
Description

Saikosaponin C is one of the major active constituents of dried Radix bupleuri root that has been widely used in China to treat a variety of conditions. Recently, saikosaponins have been reported to have properties of cell growth inhibition, inducing cancer cells differentiation and apoptosis.
In Vitro

——
In Vivo

——
Synonyms

Saikosaponin C
Pathway

Others
Target

Other Targets
Recptor

Caspase-3
Research Area

Others-Field
Indication

——

CAS Number

20736-08-7
Formula Weight

927.14
Molecular Formula

C48H72O17
Purity

>98% (HPLC)
Solubility

In Vitro:?DMSO : 100 mg/mL (107.86 mM)
SMILES

[C@@H]1([C@@H]([C@@H]([C@H]([C@@H](O1)C)O)O)O)O[C@@H]1[C@H](O[C@H]([C@@H]([C@H]1O)O)O[C@H]1CC[C@]2([C@H](C1(C)C)CC[C@]1([C@@]3(C[C@@H]([C@@]45CCC(C[C@H]4[C@]3(C=C[C@H]21)OC5)(C)C)O)C)C)C)CO[C@H]1[C@@H]([C@H]([C@@H]([C@H](O1)CO)O)O)O
Chemical Name

(2S,3R,4R,5R,6S)-2-(((2R,3R,4S,5S,6R)-4,5-dihydroxy-2-((6aR,6bS,8R,12aS,14bS)-8-hydroxy-4,4,6a,6b,11,11,14b-heptamethyl-2,3,4,4a,5,6,6a,6b,7,8,10,11,12,12a,14a,14b-hexadecahydro-1H,9H-12b,8a-(epoxymethano)picen-3-yl)-6-(hydroxymethyl)-2-(((2S,3R,4S,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)tetrahydro-2H-pyran-2-yl)oxy)tetrahydro-2H-pyran-3-yl)oxy)-6-methyltetrahydro-2H-pyran-3,4,5-triol

1.Lee TH1, Chang J2, Kim BM3. 2014 Mar 14;445(3):615-21.

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