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Gracillin
CAS No. 19083-00-2
Gracillin( Gracillin | NSC-698787 | NSC 698787 | NSC698787 )
Catalog No. M18168 CAS No. 19083-00-2
Gracillin can induce cell cycle arrest, oxidative stress, and apoptosis in HL60 cells, and has the potential to be developed as an antitumor agent.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 1 mL x 10 mM in DMSO | 65 | In Stock |
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| 2MG | 29 | In Stock |
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| 5MG | 42 | In Stock |
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| 10MG | 67 | In Stock |
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| 25MG | 128 | In Stock |
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| 50MG | 197 | In Stock |
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| 100MG | 291 | In Stock |
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| 200MG | Get Quote | In Stock |
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| 500MG | Get Quote | In Stock |
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| 1G | Get Quote | In Stock |
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Biological Information
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Product NameGracillin
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NoteResearch use only, not for human use.
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Brief DescriptionGracillin can induce cell cycle arrest, oxidative stress, and apoptosis in HL60 cells, and has the potential to be developed as an antitumor agent.
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DescriptionGracillin is a steroidal saponin that has been found in C. speciosus and has diverse biological activities. Gracillin induces apoptosis in HL60 human leukemic cell line via oxidative stress and cell cycle arrest of G1.
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In VitroApoptosis Analysis Cell Line:A549 cells Concentration:0-4 μM Incubation Time:24 h Result:Induced morphological changes.Apoptosis rate: 6.56%-67.43%.
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In Vivo——
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SynonymsGracillin | NSC-698787 | NSC 698787 | NSC698787
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PathwayOthers
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TargetOther Targets
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Recptorcell cycle arrest
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Research AreaCancer
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Indication——
Chemical Information
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CAS Number19083-00-2
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Formula Weight885.05
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Molecular FormulaC45H72O17
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Purity>98% (HPLC)
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SolubilityIn Vitro:?DMSO : 100 mg/mL (112.99 mM)
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SMILES[C@@H]1([C@@H]([C@H]([C@@H]([C@H](O1)CO)O)O)O)O[C@H]1[C@@H]([C@H](O[C@H]([C@@H]1O[C@H]1[C@@H]([C@@H]([C@H]([C@@H](O1)C)O)O)O)O[C@@H]1CC2=CC[C@H]3[C@@H]4C[C@@H]5O[C@@]6([C@H]([C@@H]5[C@]4(CC[C@@H]3[C@]2(CC1)C)C)C)CC[C@H](CO6)C)CO)O
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Chemical Name(2S,3R,4S,5R,6R)-2-(((2R,3R,4S,5R,6R)-3-hydroxy-2-(hydroxymethyl)-6-(((4S,5'R,6aR,6bS,8aR,8bR,9S,10R,11aS,12aS,12bS)-5',6a,8a,9-tetramethyl-1,3,3',4,4',5,5',6,6a,6b,6',7,8,8a,8b,9,11a,12,12a,12b-icosahydrospiro[naphtho[2',1':4,5]indeno[2,1-b]furan-10,2'-pyran]-4-yl)oxy)-5-(((2S,3R,4R,5R,6R)-3,4,5-trihydroxy-6-methyltetrahydro-2H-pyran-2-yl)oxy)tetrahydro-2H-pyran-4-yl)oxy)-6-(hydroxymethyl)tetrahydro-2H-pyran-3,4,5-triol
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1. Chen CR,et al.Gracillin induces apoptosis in HL60 human leukemic cell line via oxidative stress and cell cycle arrest of G1.Pharmazie. 2015 Mar;70(3):199-204.
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