Acetylcorynoline

Research use only, not for human use.

Acetylcorynoline may be one of the potent immunosuppressive agents through the blockage of dendritic cells maturation and function.

Acetylcorynoline has antifungal、anti-inflammatory activity. Acetylcorynoline may be one of the potent immunosuppressive agents through the blockage of dendritic cells maturation and function. Acetylcorynoline is potential as a possible antiparkinsonian drug. (1) Significantly decreases dopaminergic neuron degeneration induced by 6-hydroxydopamine in BZ555 strain; (2) Prevents α-synuclein aggregation; (3) Restores food-sensing behavior, and dopamine levels; (4) Prolongs life-span in 6-hydroxydopamine-treated N2 strain. Acetylcorynoline may exert its effects by decreasing egl-1 expression to suppress apoptosis pathways and by increasing rpn5 expression to enhance the activity of proteasomes.

Acetylcorynoline significantly inhibits the secretion of tumor necrosis factor-α, interleukin-6, and interleukin-12p70 by LPS-stimulated Dendritic cells (DCs).Acetylcorynoline significantly inhibits LPS-induced activation of IκB kinase and mitogen-activated protein kinase.

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Others

Other Targets

Antifungal

Others-Field

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18797-80-3

409.43

C23H23NO6

>98% (HPLC)

In Vitro:?DMSO : 25 mg/mL (61.06 mM)

CC(=O)OC1CC2=CC3=C(C=C2C4C1(C5=C(CN4C)C6=C(C=C5)OCO6)C)OCO3

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(-20℃)

With Ice Pack

≥ 2 years