Madecassic acid( —— )

Catalog No. M18146 CAS No. 18449-41-7

COA

Datasheet

HNMR

HPLC

MSDS

Handing Instructions

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Product Name

Madecassic acid
Note

Research use only, not for human use.
Brief Description

Madecassic acid is extracted from the whole herb of Centella asiatica.
Description

Madecassic acid is extracted from the whole herb of Centella asiatica.
In Vitro

Western Blot Analysis Cell Line:RAW 264.7 murine macrophage cell Concentration:50, 100, 150 μM Incubation Time:24 h followed by LPS (1 μg/mL) treatment for 4 h Result:Inhibited LPS-induced iNOS and COX-2 protein expression i in a dose -dependent manner.
In Vivo

Animal Model:Colitis mice induced by2.5% DSS Dosage:25?mg/kg/day Administration:Oral gavage (p.o.) , 10 days Result:Decreased the number of γδT17 cells in the colons.Reduced the expression of IL-17 in colon tissues.
Synonyms

——
Pathway

Others
Target

Other Targets
Recptor

Others
Research Area

Others-Field
Indication

——

CAS Number

18449-41-7
Formula Weight

504.71
Molecular Formula

C30H48O6
Purity

>98% (HPLC)
Solubility

In Vitro:?DMSO : 62.5 mg/mL (123.84 mM)
SMILES

C[C@@H]1CC[C@@]2(CC[C@@]3(C(=CC[C@H]4[C@]3(C[C@H]([C@@H]3[C@@]4(C[C@H]([C@@H]([C@@]3(C)CO)O)O)C)O)C)[C@@H]2[C@H]1C)C)C(=O)O
Chemical Name

——

1. Zhang H, et al. J BUON. 2014 Apr-Jun;19(2):372-6.

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