Metergoline( Metergoline )

Catalog No. M18131 CAS No. 17692-51-2

COA

Datasheet

HNMR

HPLC

MSDS

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Product Name

Metergoline
Note

Research use only, not for human use.
Brief Description

Metergoline is a dopamine agonist and serotonin antagonist. It has been used similarly to BROMOCRIPTINE as a dopamine agonist and also for migraine disorder therapy.
Description

Metergoline is a psychoactive drug of the ergoline chemical class which acts as a ligand for various serotonin and dopamine receptors. A dopamine agonist and serotonin antagonist. It has been used similarly to BROMOCRIPTINE as a dopamine agonist and also for MIGRAINE DISORDERS therapy.
In Vitro

——
In Vivo

Animal Model:Male albino mice (25-40 g)Dosage:5 mg/kg Administration:Intraperitoneal injection Result:Inhibited bites or scratches induced by 5-HT (2 μg).
Synonyms

Metergoline
Pathway

Others
Target

Other Targets
Recptor

5-HT1| 5-HT2| 5-HT2| 5-HT2| 5-HT7
Research Area

Neurological Disease
Indication

——

CAS Number

17692-51-2
Formula Weight

403.52
Molecular Formula

C25H29N3O2
Purity

>98% (HPLC)
Solubility

DMSO : 50 mg/mL 123.91 mM;H2O : < 0.1 mg/mL
SMILES

CN1C[C@@H](C[C@H]2[C@H]1Cc1cn(c3cccc2c13)C)CNC(=O)OCc1ccccc1
Chemical Name

Carbamic acid, (((8-beta)-1,6-dimethylergolin-8-yl)methyl)-, benzyl ester

1. Millan, M.J.,Newman-Tancredi, A.,Lochon, S., et al. Biochem. Behav. 71(4), 589-598 (2002).

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