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Ginkgolide B
CAS No. 15291-77-7
Ginkgolide B( Bilobalide B | Ginkgolide B | BN 52021 )
Catalog No. M18066 CAS No. 15291-77-7
Ginkgolide B is a PAFR antagonist(IC50=3.6 μM) isolated from Ginkgo biloba.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 1 mL x 10 mM in DMSO | 60 | In Stock |
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| 5MG | 29 | In Stock |
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| 10MG | 35 | In Stock |
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| 25MG | 54 | In Stock |
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| 50MG | 90 | In Stock |
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| 100MG | 128 | In Stock |
|
| 200MG | Get Quote | In Stock |
|
| 500MG | 321 | In Stock |
|
| 1G | Get Quote | In Stock |
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Biological Information
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Product NameGinkgolide B
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NoteResearch use only, not for human use.
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Brief DescriptionGinkgolide B is a PAFR antagonist(IC50=3.6 μM) isolated from Ginkgo biloba.
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DescriptionGinkgolide B is a GlyR agonist found in Ginkgo. It inhibits ATP release from thrombin-activated platelets, protects neurons against ischemic injury, prevents edema and inflammation, and increases activation of PKA, Ca+2 signaling, and glutamate release.
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In VitroWestern Blot Analysis Cell Line:HUVECs Concentration:30, 60, 150 μM Incubation Time:24 hResult:Inhibited the up-regulation of VCAM-1 and E-selectin protein expression induced by TNF-α.RT-PCRCell Line:HUVECs Concentration:30, 60, 150 μM Incubation Time:24, 48 h Result:Increased CYP3A4 mRNA and MDR1 expression after 24 h, and this effect was dose-dependent after 48 h.
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In VivoAnimal Model:Male clean healthy Sprague-Dawley rats, weighing 250-280 g and aged 8 weeksDosage:20 mg/kg Administration:Intraperitoneally; immediately and 6 hours after ischemia, and thereafter once daily; 14 days Result:Decreased the neurological deficit score, increased the proportion of nestin-, neuron-specific enolase- and glial fibrillary acid protein-positive cells. Caused down-regulation of NSE protein at day 14.
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SynonymsBilobalide B | Ginkgolide B | BN 52021
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PathwayOthers
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TargetOther Targets
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RecptorPAFR
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Research AreaOthers-Field
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Indication——
Chemical Information
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CAS Number15291-77-7
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Formula Weight424.4
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Molecular FormulaC20H24O10
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Purity>98% (HPLC)
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SolubilityDMSO : ≥ 30 mg/mL; 70.69 mM
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SMILESO1[C@H]2[C@@H](O)[C@]34[C@@H]5OC(=O)[C@]3(O[C@@H]3OC(=O)[C@H](O)[C@]43[C@H](C(C)(C)C)C5)[C@@]2(O)[C@H](C)C1=O
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Chemical Name5H-Dicyclopenta(b,c)furan-3,5a(6H)-diacetic acid, 6-tert-butyl-3a-carboxyhexahydro-alpha5a,1,2,3,5,8-hexahydroxy-alpha3-methyl-, tri-gamma-lactone
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
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Desacetyl Forskolin
Deacetylforskolin is a deacetylated derivative of forskolin that can be extracted from C. forskohlii. Deacetylforskolin activates rat adipocyte adenylyl cyclase (IC50 = 20 μM), inhibits glucose transport in rat adipocyte plasma membranes and exhibits antihypertensive activity.
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Taltirelin
Taltirelin is at thyrotropin-releasing hormone receptor (TRH-R) superagonist (IC50 of 910 nM and EC50 of 36 nM for stimulating an increase in cytosolic Ca2+ concentration (Ca2+ release).
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γ-2-MSH (41-58), ami...
Melanocortin (MC) 3-MSH (Melanocyte-Stimulating Hormone) is believed to signal through the MC 3 receptor. It induces a sustained increase in intracellular free calcium levels ([Ca2+]i) in a subpopulation of pituitary cells. Most of the cells responding to 3-MSH express more than one pituitary hormone mRNA. The effect of 3-MSH is blocked by SHU9119, a MC3R and MC4R antagonist, in only 50% of the responsive cells, suggesting that in half of these cells the mediating receptor is not the MC3R. Low picomolar doses of 3-MSH increase [Ca2+]i in the growth hormone (GH)- and prolactin (PRL)-secreting GH3 cell line.
