ML297( ML297 | ML 297 | ML-297 )

Catalog No. M18019 CAS No. 1443246-62-5

COA

Datasheet

HNMR

HPLC

MSDS

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Product Name

ML297
Note

Research use only, not for human use.
Brief Description

ML297 is a selective Kir3.1/3.2 (GIRK1/2) channel activator (IC50 values are 160, 887 and 914 nM for GIRK1/2, GIRK1/4 and GIRK1/3 respectively).
Description

ML297 is a selective Kir3.1/3.2 (GIRK1/2) channel activator (IC50 values are 160, 887 and 914 nM for GIRK1/2, GIRK1/4 and GIRK1/3 respectively). ML297 exhibits no effect on GIRK2, GIRK2/3, Kir2.1 and Kv7.4 channels, and has minimal effect on a panel of other ion channels, receptors and transporters.
In Vitro

ML 297 is completely inactive for GIRK2/3.ML297 shows concentration-dependent efficacy in expressing GIRK1/2 cells and with an EC50 of 162 nM. ML297 shows a complete inability to modulate the activity of HEK-293 cells expressing GIRK2 alone and GIRKGIRK2/3.
In Vivo

ML297 (60 mg/kg; i.p.) shows a highly significant ability to both prevent convulsions and prevent fatality of the PTZ treatment. Animal Model:8-10 months old C57/BL6 male mice (approximately 30 g)Dosage:60 mg/kg Administration:Intraperitoneal injectionResult:Most of the animals neither convulsions nor death.
Synonyms

ML297 | ML 297 | ML-297
Pathway

Others
Target

Other Targets
Recptor

GIRK1/2
Research Area

——
Indication

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1.Nimitvilai S, Lopez MF, Mulholland PJ, Woodward JJ. Neuropsychopharmacology. 2017 Aug;42(9):1800-1812.

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