Naratriptan hydrochloride( Naratriptan HCl | Amerge | Naramig | GR-85548A )

Catalog No. M18015 CAS No. 143388-64-1

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Product Name

Naratriptan hydrochloride
Note

Research use only, not for human use.
Brief Description

Naratriptan Hydrochloride is the hydrochloride salt form of naratriptan, a sulfonamide with selective serotonin (5-HT) 1 receptor agonistic activity and anti-migraine property.
Description

Naratriptan Hydrochloride is the hydrochloride salt form of naratriptan, a sulfonamide with selective serotonin (5-HT) 1 receptor agonistic activity and anti-migraine property. Naratriptan hydrochloride binds selectively and with high affinity to the 5-HT1D and 5-HT1B receptor subtypes. Activation of these 5-HT1D/B receptors located on intracranial blood vessels leads to vasoconstriction and provides relief of migraine headaches. Naratriptan hydrochloride may also exerts its effect by stimulation of 5-HT1D/1B receptors on sensory nerve endings in the trigeminal system thereby decreasing the release of pro-inflammatory neuropeptides.
In Vitro

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In Vivo

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Synonyms

Naratriptan HCl | Amerge | Naramig | GR-85548A
Pathway

Others
Target

Other Targets
Recptor

5-HT1
Research Area

Neurological Disease
Indication

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CAS Number

143388-64-1
Formula Weight

371.93
Molecular Formula

C17H25N3O2S·HCl
Purity

>98% (HPLC)
Solubility

DMSO : ≥ 35 mg/mL; 94.10 mM
SMILES

CNS(=O)(=O)CCc1cc2c(cc1)[nH]cc2C1CCN(CC1)C.Cl
Chemical Name

N-Methyl-2-[3-(1-methylpiperidin-4-yl)-1H-indol-5-yl]ethanesulfonamide hydrochloride

1.Sattar M, Hadgraft J, Lane ME.Int J Pharm. 2015 Sep 30;493(1-2):146-51.

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