Chetomin( Chetomin | CTM | NSC-289491 | NSC 289491 )

Catalog No. M17999 CAS No. 1403-36-7

COA

Datasheet

HNMR

HPLC

MSDS

Handing Instructions

Get Quotation Bulk Inquiry Add to Cart

Product Name

Chetomin
Note

Research use only, not for human use.
Brief Description

Chetomin is an inhibitor of HIF-1 by weaken transcription of HIF-1, disrupting the binding of HIF-1α and HIF-2α to p300 at low nanomolar concentrations.
Description

Chetomin is a natural product isolated from Chaetomium species which has antibacterial and antifungal properties. Chetomin induces degradation of XIAP and enhances TRAIL sensitivity in urogenital cancer cells. Chetomin, targeting HIF-1α/p300 complex, exhibits antitumour activity in multiple myeloma.
In Vitro

Western Blot Analysis Cell Line:H460 and H1299 cells Concentration:0~10 μM Incubation Time:24 hours Result:Showed progressively lower expression of several survival-promoting proteins promoted by Hsp90/HIF1α activity, including insulin-like growth factor 1 (IGF1 R), epidermal growth factor receptor (EGFR), Src, mitogen-activated protein kinase kinase 1/2 (MEK1/2), activation of protein kinase B (Akt), and mammalian target of rapamycin (mTOR).Cell Cycle Analysis Cell Line:H1299 cells Concentration:0~10 μM Incubation Time:24 hours Result:Elicited cell cycle arrest in susceptible and chemoresistant NSCLC cell lines.
In Vivo

Animal Model:Mouse Dosage:0~100 mg/kg Administration:P.o.Result:Inhibited lung tumorigenesis in NSCLC mouse models.
Synonyms

Chetomin | CTM | NSC-289491 | NSC 289491
Pathway

Others
Target

Other Targets
Recptor

HIF-1
Research Area

Cancer
Indication

——

CAS Number

1403-36-7
Formula Weight

710.87
Molecular Formula

C31H30N6O6S4
Purity

>98% (HPLC)
Solubility

——
SMILES

CN1C(=O)C23CC4(C(N2C(=O)C1(SS3)CO)NC5=CC=CC=C54)C67CC89C(=O)N(C(C(=O)N8C6NC1=CC=CC=C71)(SS9)CO)C
Chemical Name

2,3S,5aR,6,10bS,11-hexahydro-3-(hydroxymethyl)-10b-[(1S,4S)-3-[[4-(hydroxymethyl)-5,7-dimethyl-6,8-dioxo-2,3-dithia-5,7-diazabicyclo[2.2.2]oct-1-yl]methyl]-1H-indol-1-yl]-2-methyl-3,11aS-epidithio-11aH-pyrazino[1',2':1,5]pyrrolo[2,3-b]indole-1,4-dione