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Donepezil HCl

CAS No. 120011-70-3

Donepezil HCl( E2020 )

Catalog No. M17875 CAS No. 120011-70-3

Donepezil is a selective and effective AChE inhibitor for bAChE and hAChE (IC50: 8.12/11.6 nM).

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
Size Price / USD Stock Quantity
1 mL x 10 mM in DMSO 65 In Stock
25MG 42 In Stock
50MG 59 In Stock
100MG 79 In Stock
200MG 120 In Stock
500MG 201 In Stock
1G Get Quote In Stock
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Biological Information

  • Product Name
    Donepezil HCl
  • Note
    Research use only, not for human use.
  • Brief Description
    Donepezil is a selective and effective AChE inhibitor for bAChE and hAChE (IC50: 8.12/11.6 nM).
  • Description
    Donepezil is a selective and effective AChE inhibitor for bAChE and hAChE (IC50: 8.12/11.6 nM).
  • In Vitro
    Cell Viability Assay Cell Line:Cortical neuronal cellsConcentration:0.01, 0.1, 1, and 10 μM Incubation Time:24 hours Result:Exhibited significantly increased cell viability (maximized 89.2±2.1% in MTT, 96.3±5.5% in TBS, and 95.1±3.2% in CCK-8). Western Blot Analysis Cell Line:Cortical neuronal cells Concentration:10 μM Incubation Time:24 hours before 20 μM Aβ42 exposure for 6 hours Result:Effects of Donepezil on Akt and the GSK-3 signaling pathway were statistically significant in the presence of Aβ42 toxicity.
  • In Vivo
    Animal Model:Male imprinting control region (ICR) mice (6 weeks old)Dosage:3-10 mg/kg Administration:Administered orallyResult:Pretreatment with 3–10 mg/kg ameliorated scopolamine-induced memory impairment. Animal Model:Hairless rats with an average weight of 300 g Dosage:3 and 10 mg/kg (Pharmacokinetic Analysis)Administration:Administered orally; and blood (250 μL) was collected through the tail vein Result:After oral treatment (3 and 10 mg/kg), a maximum concentration (Cmax) was reached after approximately 1.2 ± 0.4 h and 1.4 ± 0.5 h, respectively, and gradually decreased.
  • Synonyms
    E2020
  • Pathway
    Others
  • Target
    Other Targets
  • Recptor
    bAChE| hAChE
  • Research Area
    Neurological Disease
  • Indication
    ——

Chemical Information

  • CAS Number
    120011-70-3
  • Formula Weight
    416
  • Molecular Formula
    C24H29NO3·HCl
  • Purity
    >98% (HPLC)
  • Solubility
    H2O : 33.33 mg/mL 80.13 mM; DMSO : 6.2 mg/mL 14.91 mM
  • SMILES
    Cl.COc1c(OC)cc2C(=O)C(CC3CCN(Cc4ccccc4)CC3)Cc2c1
  • Chemical Name
    ——

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1. Ogura H, et al. Methods Find Exp Clin Pharmacol. 2000, 22(8), 609-613.
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