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Fumaric acid
CAS No. 110-17-8
Fumaric acid( Fumaric acid | Kyselina fumarova | Lichenic acid )
Catalog No. M17809 CAS No. 110-17-8
Fumaric acid attenuates the eotaxin-1 expression in TNF-α-stimulated fibroblasts by suppressing p38 MAPK-dependent NF-κB signaling.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 1 mL x 10 mM in DMSO | 28 | In Stock |
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| 25MG | 49 | In Stock |
|
| 100MG | Get Quote | In Stock |
|
| 200MG | Get Quote | In Stock |
|
| 500MG | Get Quote | In Stock |
|
| 1G | Get Quote | In Stock |
|
Biological Information
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Product NameFumaric acid
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NoteResearch use only, not for human use.
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Brief DescriptionFumaric acid attenuates the eotaxin-1 expression in TNF-α-stimulated fibroblasts by suppressing p38 MAPK-dependent NF-κB signaling.
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DescriptionFumaric acid is a dicarboxylic acid. It is a oncometabolite or an endogenous, cancer causing metabolite. High levels of this organic acid can be found in tumors or biofluids surrounding tumors. Its oncogenic action appears to due to its ability to inhibit prolyl hydroxylase-containing enzymes.
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In VitroWestern Blot Analysis Cell Line:NIH/3T3 Concentration:50 μM Incubation Time:24 h Result:Inhibited p38 MAPK and IκB-a phosphorylation.Attenuated TNF-a-induced NF-κB and decreased the expression of CCR3. Reduced the NF-κB activation induced by TRADD, TRAF2, and MEKK3.
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In VivoAnimal Model:Gestational hypertension rat modelDosage:10 mL/kg Administration:i.v.Result:Downregulated the levels of TET1 and KCNMB1.
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SynonymsFumaric acid | Kyselina fumarova | Lichenic acid
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PathwayEndocrinology/Hormones
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TargetTHR
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RecptorOthers
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Research Area——
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Indication——
Chemical Information
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CAS Number110-17-8
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Formula Weight116.1
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Molecular FormulaC4H4O4
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Purity>98% (HPLC)
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SolubilityIn Vitro:?DMSO : 25 mg/mL (215.39 mM)
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SMILESC(=C/C(=O)O)\C(=O)O
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Chemical Name2-Butenedioic acid (2E)-
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1. Chen X, et al. Fumaric acid production by Torulopsis glabrata: engineering the urea cycle and the purine nucleotide cycle. Biotechnol Bioeng. 2015 Jan;112(1):156-67.
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