Polaprezinc

Research use only, not for human use.

Polaprezinc is an orally bioavailable chelate composed of zinc and L-carnosine, with potential gastroprotective, anti-ulcer, anti-oxidant and anti-inflammatory activities.

Polaprezinc is an orally bioavailable chelate composed of zinc and L-carnosine, with potential gastroprotective, anti-oxidant, anti-ulcer and anti-inflammatory activities. Upon administration, polaprezinc increases the expression of various anti-oxidant enzymes, such as superoxide dismutase 1 (SOD-1), SOD-2, heme oxygenase-1 (HO-1), glutathione S-transferase (GST), glutathione peroxidase (GSH-px), peroxidredoxin-1 (PRDX1; PRXI) and PRXD5 (PRXV) in the gastric mucosa, which protect cells against reactive oxygen species (ROS).

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Polaprezinc (PZ) is an antiulcer drug and a chelating compound consisting of a zinc ion, L-carnosine, a β-alanine dipeptide and L-histidine. Polaprezinc exerts antioxidant effects and scavenges free radicals. The efficacy of Polaprezinc is reported for acute radiation proctitis in an animal model and demonstrates that Polaprezinc has an anti-inflammatory effect following exposure to radiation.

Polaprezinc | Z 103

Others

Other Targets

Others

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107667-60-7

289.63

C9H12N4O3Zn

>98% (HPLC)

H2O : 3.37 mg/mL 11.68 mM; DMSO : < 1 mg/mL

NCCC(=O)N1[Zn]OC(=O)[C@@H]1Cc1cnc[nH]1

catena-Poly(zinc-mu-(beta-alanyl-L-histidinato(2(-))-N,N(sup N),O:N(sup tau)))

(-20℃)

With Ice Pack

≥ 2 years