Shionone

Research use only, not for human use.

Shionone has anti-tussive and anti-inflammatory effects.

Shionone is an effective inhibitor of human neutrophil elastase which may be used as a treatment for inflammatory lung diseases including H1N1 and SARS virus infections. Shiononeis a tetracyclic triterpenoid is the major triterpenoid component of Aster tataricus possessing a unique all six-membered tetracyclic skeleton and 3-oxo-4-monomethyl structure. is perhydrochrysene which is substituted by methyl groups at positions 1, 4bβ, 6aα, 8β, 10aβ and 12a positions, by a 4-methylpent-3-enyl group at the 8α position, and with an oxo group at position 2.

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Shionone (orally administration; 80 mg/kg; 3 days; once daily) shows the trend of enhancing sputum secreting, but has no effect on ammonia-induced cough and reduces xylene-induced ear edema. Animal Model:ICR male mice Dosage:80 mg/kg Administration:Orally administration; 3 days; once daily Result:Reduced the ear edema for 11.3% by use shionone.

Shionone | UNII-BT0AMD31UB

Others

Other Targets

Others

Inflammation/Immunology

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10376-48-4

426.72

C30H50O

>98% (HPLC)

In Vitro:?Ethanol : 2 mg/mL (4.69 mM)

CC1C(=O)CCC2C1(CCC3C2(CCC4(C3(CCC(C4)(C)CCC=C(C)C)C)C)C)C

(1R,4aS,4bS,6aS,8R,10aR,10bS,12aS)-1,4b,6a,8,10a,12a-hexamethyl-8-(4-methylpent-3-en-1-yl)hexadecahydrochrysen-2(1H)-one

(-20℃)

With Ice Pack

≥ 2 years