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Rg3039

CAS No. 1005504-62-0

Rg3039( RG3039 | RG 3039 | PF 06687859 | PF-06687859 )

Catalog No. M17746 CAS No. 1005504-62-0

RG3039 (PF-06687859) is a potent DcpS inhibitor.

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
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2MG 30 In Stock
5MG 48 In Stock
10MG 80 In Stock
25MG 157 In Stock
50MG 253 In Stock
100MG 407 In Stock
200MG Get Quote In Stock
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Biological Information

  • Product Name
    Rg3039
  • Note
    Research use only, not for human use.
  • Brief Description
    RG3039 (PF-06687859) is a potent DcpS inhibitor.
  • Description
    RG3039, also known as PF-06687859, is a potent DcpS inhibitor. DcpS is a therapeutic target for spinal muscular atrophy. Spinal muscular atrophy (SMA) is caused by deletion or mutation of both copies of the SMN1 gene which produces an essential protein known as SMN. RG3039 improves motor function in SMA mice. RG3039 also showed activity to improve survival, function and motor unit pathologies in two SMA mouse models.
  • In Vitro
    ——
  • In Vivo
    ——
  • Synonyms
    RG3039 | RG 3039 | PF 06687859 | PF-06687859
  • Pathway
    Cell Cycle/DNA Damage
  • Target
    GPR
  • Recptor
    DcpS
  • Research Area
    ——
  • Indication
    ——

Chemical Information

  • CAS Number
    1005504-62-0
  • Formula Weight
    432.35
  • Molecular Formula
    C21H23Cl2N5O
  • Purity
    >98% (HPLC)
  • Solubility
    DMSO : 6 mg/mL 13.88 mM; H2O : < 0.1 mg/mL
  • SMILES
    C1CN(CCC1COc1cccc2c1c(nc(n2)N)N)Cc1c(cccc1Cl)Cl
  • Chemical Name
    5-((1-(2,6-dichlorobenzyl)piperidin-4-yl)methoxy)quinazoline-2,4-diamine

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1. Rocky G. Gogliotti, et al. Hum Mol Genet. 2013 Oct 15; 22(20): 4084–4101.
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