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BMS-303141
CAS No. 943962-47-8
BMS-303141( BMS303141 | BMS-303141 | BMS 303141 )
Catalog No. M17681 CAS No. 943962-47-8
BMS-303141 is a potent ATP-citrate lyase (ACL) inhibitor (IC50: 0.13 uM, human recombinant ACL).
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 2MG | 35 | In Stock |
|
| 5MG | 55 | In Stock |
|
| 10MG | 71 | In Stock |
|
| 25MG | 129 | In Stock |
|
| 50MG | 254 | In Stock |
|
| 100MG | 399 | In Stock |
|
| 500MG | 893 | In Stock |
|
| 1G | Get Quote | In Stock |
|
Biological Information
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Product NameBMS-303141
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NoteResearch use only, not for human use.
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Brief DescriptionBMS-303141 is a potent ATP-citrate lyase (ACL) inhibitor (IC50: 0.13 uM, human recombinant ACL).
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DescriptionBMS303141 is a potent inhibitor of ATP citrate lyase (ACL). BMS-303141 inhibits lipid synthesis in HepG2 cells with an IC50 of 8 μM, and lowers plasma triglycerides in a murine hyperlipdemia model.
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In VitroIn HepG2 cells, BMS-303141 shows inhibition of total lipid syntheses with an IC50 of 8 μM. BMS-303141 shows no cytotoxicity up to 50 lM under a cell based Alamar Blue cytotoxicity assay, indicating the observed inhibition of lipid synthesis is not a result of compound-induced cytotoxicity.
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In VivoChronic oral dosing of BMS-303141 in high-fat fed mice lowers approximate 20-30% plasma cholesterol and triglycerides, as well as 30-50% fasting plasma glucose. Chronic treatment with BMS-303141 shows a gradual inhibition of weight gain along with a reduction in adiposity without apparent changes in food intake. BMS-303141 shows an oral bioavailability of 55% but a relatively short half-life of 2.1 h.
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SynonymsBMS303141 | BMS-303141 | BMS 303141
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PathwayEndocrinology/Hormones
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TargetAChR
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RecptorACL
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Research AreaMetabolic Disease
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Indication——
Chemical Information
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CAS Number943962-47-8
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Formula Weight424.3
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Molecular FormulaC19H15Cl2NO4S
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Purity>98% (HPLC)
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SolubilityDMSO : ≥ 47 mg/mL; 110.77 mM
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SMILESc1c(cccc1)c1cc(c(cc1)OC)NS(=O)(=O)c1c(O)c(cc(c1)Cl)Cl
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Chemical Name3,5-Dichloro-2-hydroxy-N-(4-methoxy[1,1′-biphenyl]-3-yl)-benzenesulfonamide
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1. Li JJ, et al. Bioorg Med Chem Lett. 2007 Jun 1;17(11):3208-11.
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