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TG100713

CAS No. 925705-73-3

TG100713( TG100713 )

Catalog No. M17665 CAS No. 925705-73-3

TG100713 is a pan-PI3K inhibitor against PI3Kγ, PI3Kδ, PI3Kα and PI3Kβ with IC50 of 50 nM, 24 nM, 165 nM and 215 nM, respectively.

Purity : >98% (HPLC)

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Biological Information

Product Name

TG100713
Note

Research use only, not for human use.
Brief Description

TG100713 is a pan-PI3K inhibitor against PI3Kγ, PI3Kδ, PI3Kα and PI3Kβ with IC50 of 50 nM, 24 nM, 165 nM and 215 nM, respectively.
Description

TG100713 is an inhibitor of PI3-kinase (IC50 values are 24, 50, 165 and 215 nM for PI3Kδ, γ, α and β isoforms respectively). Inhibits endothelial cell proliferation.
In Vitro

TG100713 (10 μM; 48 or 72 h) strongly inhibits endothelial cell (EC) proliferation.
In Vivo

——
Synonyms

TG100713
Pathway

Cell Cycle/DNA Damage
Target

ROCK
Recptor

PI3Kδ , PI3Kγ , PI3Kα , PI3Kβ
Research Area

Cancer
Indication

——

Chemical Information

CAS Number

925705-73-3
Formula Weight

254.25
Molecular Formula

C12H10N6
Purity

>98% (HPLC)
Solubility

In Vitro:?DMSO : 6.41 mg/mL (25.21 mM)
SMILES

C1=CC(=CC(=C1)O)C2=CN=C3C(=N2)C(=NC(=N3)N)N
Chemical Name

3-(2,4-diaminopteridin-6-yl)phenol

Shipping & Storage Information

Storage

(-20℃)
Shipping

With Ice Pack
Stability

≥ 2 years

Reference

1. Doukas J et al. Proc Natl Acad Sci U S A, 2006, 103(52), 19866-19871.

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