ML221

CAS No. 877636-42-5

ML221( ML221 | ML 221 | ML-221 )

Catalog No. M17640 CAS No. 877636-42-5

ML221 is a potent apelin /APJ functional antagonist, inhibiting apelin-13-mediated activation of APJ, with IC50s of 0.70 μM in the cAMP assay, and 1.75 μM in the β-arrestin assay, and EC80 of 10 nM in both assays.

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
Size Price / USD Stock Quantity
1 mL x 10 mM in DMSO 48 In Stock
2MG 29 In Stock
5MG 46 In Stock
10MG 73 In Stock
25MG 140 In Stock
50MG 222 In Stock
100MG 361 In Stock
200MG 528 In Stock
500MG Get Quote In Stock
1G Get Quote In Stock

Biological Information

  • Product Name
    ML221
  • Note
    Research use only, not for human use.
  • Brief Description
    ML221 is a potent apelin /APJ functional antagonist, inhibiting apelin-13-mediated activation of APJ, with IC50s of 0.70 μM in the cAMP assay, and 1.75 μM in the β-arrestin assay, and EC80 of 10 nM in both assays.
  • Description
    ML221 is a potent apelin /APJ functional antagonist, inhibiting apelin-13-mediated activation of APJ, with IC50s of 0.70 μM in the cAMP assay, and 1.75 μM in the β-arrestin assay, and EC80 of 10 nM in both assays.
  • In Vitro
    ——
  • In Vivo
    ——
  • Synonyms
    ML221 | ML 221 | ML-221
  • Pathway
    Others
  • Target
    Other Targets
  • Recptor
    APJ
  • Research Area
    Neurological Disease
  • Indication
    ——

Chemical Information

  • CAS Number
    877636-42-5
  • Formula Weight
    385.35
  • Molecular Formula
    C17H11N3O6S
  • Purity
    >98% (HPLC)
  • Solubility
    DMSO : ≥ 31 mg/mL; 80.45 mM
  • SMILES
    C1=CN=C(N=C1)SCC2=CC(=O)C(=CO2)OC(=O)C3=CC=C(C=C3)[N+](=O)[O-]
  • Chemical Name
    [4-oxo-6-(pyrimidin-2-ylsulfanylmethyl)pyran-3-yl] 4-nitrobenzoate

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1. Maloney PR, etal.Bioorg Med Chem Lett. 2012 Nov 1;22(21):6656-60.
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