K03861

Research use only, not for human use.

K03861 is a type II CDK2 inhibitor with Kd of 50 nM, 18.6 nM, 15.4 nM, and 9.7 nM for CDK2(WT), CDK2(C118L), CDK2(A144C), and CDK2(C118L/A144C), respectlvely.

AUZ454 is a potent and selective Type II FLT3 inhibitor. AUZ454 is able to override drug resistance that less potent "type I" inhibitors and "type II" first-generation FLT3 inhibitors cannot. Constitutively activated mutant FLT3 has emerged as a promising target for therapy for the subpopulation of acute myeloid leukemia (AML) patients who harbor it. The small molecule inhibitor, PKC412, targets mutant FLT3 and is currently in late-stage clinical trials. However, the identification of PKC412-resistant leukemic blast cells in the bone marrow of AML patients has propelled the development of novel and structurally distinct FLT3 inhibitors that have the potential to override drug resistance and more efficiently prevent disease progression or recurrence.

Cell Proliferation Assay Cell Line:Caki-1 and ACHN cells Concentration:10?μM; 20?μM Incubation Time:1, 2, 3, and 4?days Result:Inhibited cell proliferation in a CDK2-dependent manner.

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AUZ454 | AUZ 454 | AUZ-454 | K03861

Others

Other Targets

CDK2(A144C)| CDK2(C118L)| CDK2(C118L/A144C)| CDK2(WT)

Cancer

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853299-07-7

501.5

C24H26F3N7O2

>98% (HPLC)

DMSO : ≥ 33 mg/mL; 65.80 mM

CN1CCN(CC2=CC=C(NC(=O)NC3=CC=C(OC4=NC(N)=NC=C4)C=C3)C=C2C(F)(F)F)CC1

1-(4-((2-aminopyrimidin-4-yl)oxy)phenyl)-3-(4-((4-methylpiperazin-1-yl)methyl)-3-(trifluoromethyl)phenyl)urea

(-20℃)

With Ice Pack

≥ 2 years