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KW-2478
CAS No. 819812-04-9
KW-2478( —— )
Catalog No. M17604 CAS No. 819812-04-9
KW-2478 is a non-ansamycin HSP90 inhibitor with IC50 of 3.8 nM.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 2MG | 86 | In Stock |
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| 5MG | 152 | In Stock |
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| 10MG | 221 | In Stock |
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| 25MG | 410 | In Stock |
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| 50MG | 591 | In Stock |
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| 100MG | 799 | In Stock |
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| 200MG | Get Quote | In Stock |
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| 500MG | Get Quote | In Stock |
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| 1G | Get Quote | In Stock |
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Biological Information
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Product NameKW-2478
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NoteResearch use only, not for human use.
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Brief DescriptionKW-2478 is a non-ansamycin HSP90 inhibitor with IC50 of 3.8 nM.
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DescriptionKW-2478 is a non-ansamycin HSP90 inhibitor with IC50 of 3.8 nM.(In Vitro):KW-2478 is an inhibitor of Hsp90, with an IC50 of 3.8 nM for Hsp90α. KW-2478 shows anti-proliferative activity against multiple myeloma (MM) and non-Hodgkin’s lymphoma (NHL), with GI50s of 0.30 μM (OPM-2/GFP), 0.34 μM (KMS-11), 0.39 μM (RPMI 8226), 0.12 μM (NCI-H929), 0.36 μM (Raji), 0.098 μM (SR), and 0.33 μM μM (SC-1). KW-2478 also inhibits the transcription of c-Maf and Cyclin D1 genes by mainly suppressing the function of Cdk9.(In Vivo):KW-2478 (25-200 mg/kg, i.v.) inhibits tumor growth in combined immunodeficiency (SCID) mice bearing NCI-H929 cells, without body weight loss. KW-2478 (100 mg/kg, i.v.) causes degradation of the Hsp90 client proteins (IGF-1Rβ, c-Raf-1, Cdk9) levels and dephosphorylated Erk1/2 proteins in NCI-H929 tumors of mice.
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In VitroKW-2478 is an inhibitor of Hsp90, with an IC50 of 3.8 nM for Hsp90α. KW-2478 shows anti-proliferative activity against multiple myeloma (MM) and non-Hodgkin’s lymphoma (NHL), with GI50s of 0.30 μM (OPM-2/GFP), 0.34 μM (KMS-11), 0.39 μM (RPMI 8226), 0.12 μM (NCI-H929), 0.36 μM (Raji), 0.098 μM (SR), and 0.33 μM μM (SC-1). KW-2478 also inhibits the transcription of c-Maf and Cyclin D1 genes by mainly suppressing the function of Cdk9.
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In VivoKW-2478 (25-200 mg/kg, i.v.) inhibits tumor growth in combined immunodeficiency (SCID) mice bearing NCI-H929 cells, without body weight loss. KW-2478 (100 mg/kg, i.v.) causes degradation of the Hsp90 client proteins (IGF-1Rβ, c-Raf-1, Cdk9) levels and dephosphorylated Erk1/2 proteins in NCI-H929 tumors of mice.
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Synonyms——
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PathwayEndocrinology/Hormones
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Target5-HT Receptor
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RecptorHSP90
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Research AreaCancer
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Indication——
Chemical Information
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CAS Number819812-04-9
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Formula Weight574.66
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Molecular FormulaC30H42N2O9
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Purity>98% (HPLC)
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SolubilityDMSO : ≥ 83.3 mg/mL; 144.96 mM
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SMILESCCc1c(O)cc(O)c(C(=O)c2cc(OC)c(OCCN3CCOCC3)cc2)c1CC(=O)N(CCOC)CCOC
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Chemical Name——
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1. Takayuki Nakashima, et al. Clin Y Res, 2010, 16(10), 2792-2802.
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