SBC-115076( SBC-115076 | SBC 115076 | SBC115076. )

Catalog No. M17523 CAS No. 489415-96-5

COA

Datasheet

HNMR

HPLC

MSDS

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Product Name

SBC-115076
Note

Research use only, not for human use.
Brief Description

SBC-115076 is a potent extracellular proprotein convertase subtilisin kexin type 9 (PCSK9) antagonist.
Description

SBC-115076 is a potent extracellular proprotein convertase subtilisin kexin type 9 (PCSK9) antagonist.
In Vitro

——
In Vivo

Animal Model:Female Wistar rats (high-fat diet (HFD)- fed) Dosage:4 mg/kg Administration:S.c.; daily for 3 weeks Result:Superior to atorvastatin in instigating weight loss, cholesterol reduction, and attenuation of mitochondrial oxidative stress in oxidative muscle fibers of obese female rats.
Synonyms

SBC-115076 | SBC 115076 | SBC115076.
Pathway

Tyrosine Kinase
Target

Src
Recptor

PCSK9
Research Area

Cardiovascular Disease
Indication

——

CAS Number

489415-96-5
Formula Weight

527.61
Molecular Formula

C31H33N3O5
Purity

>98% (HPLC)
Solubility

DMSO : ≥ 32 mg/mL; 60.65 mM
SMILES

Cc1cc(C(=O)C2=C(O)C(=O)N(C2c2ccncc2)CCCN2CCOCC2)ccc1OCc1ccccc1
Chemical Name

4-(4-(benzyloxy)-3-methylbenzoyl)-3-hydroxy-1-(3-morpholinopropyl)-5-(pyridin-4-yl)-1H-pyrrol-2(5H)-one

1. Abdel-Meguid SS, et al. WO2014150326 A1.

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