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ISO-1
CAS No. 478336-92-4
ISO-1( ISO-1 | ISO 1 | ISO1 | MIF Antagonist )
Catalog No. M17520 CAS No. 478336-92-4
ISO-1 is an inhibitor of the dopachrome tautomerase activity, blocks the activation of NF-κB and TNF-α secretion from LPS-treated macrophages.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 1 mL x 10 mM in DMSO | 67 | In Stock |
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| 2MG | 37 | In Stock |
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| 5MG | 61 | In Stock |
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| 10MG | 93 | In Stock |
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| 25MG | 174 | In Stock |
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| 50MG | 299 | In Stock |
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| 100MG | 477 | In Stock |
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| 200MG | Get Quote | In Stock |
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| 500MG | 814 | In Stock |
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| 1G | Get Quote | In Stock |
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Biological Information
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Product NameISO-1
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NoteResearch use only, not for human use.
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Brief DescriptionISO-1 is an inhibitor of the dopachrome tautomerase activity, blocks the activation of NF-κB and TNF-α secretion from LPS-treated macrophages.
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DescriptionISO-1, also known as MIF Antagonist and ISO-1 and Macrophage Migration Inhibitory Factor, is a MIF inhibitor. ISO-1 has CAS#478336-92-4. MDK-6924 Protects Photoreceptors and Reduces Gliosis in Experimental Retinal Detachment. Systemic administration of the MIF inhibitor ISO-1 significantly blocked photoreceptor apoptosis, outer nuclear layer (ONL) thinning, and retinal gliosis. ISO-1 and MIF knockout (MIFKO) had greater accumulation of Müller glia pERK expression in the detached retina, suggesting that Müller survival pathways might underlie the neuroprotective response.
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In VitroISO-1 (0.1-20 μM; 16 hours) has a slight inhibitory effect on Cox-2 secretion without the addition of recombinant MIF. Western Blot Analysis Cell Line:RAW 264.7 macrophage cells Concentration: 0.1μM， 1μM，10μM，20μM Incubation Time:16 hours Result:SuppressedCox-2 secretion.
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In VivoISO-1 (injected intraperitoneally; 3.5-35 mg/kg; twice daily; 2 weeks) improves the survival rate from lethal endotoxemia and shows the anti-inflammatory effect.ISO-1 (intraperitoneal injection; 35 mg/kg; twice daily; 3 days) causes a significant reduction in average implant size and decreases Flk1 expression in implants. Animal Model: C57Bl/6 MIF+/+ and MIF–/– mice Dosage:3.5-35 mg/kg Administration:Injected intraperitoneally; 3.5-35 mg/kg; twice a day ; 2 weeks Result:Was protective against lethal sepsis.Animal Model:Female C57BL/6-Tg(ACTB-EGFP)1Osb/J mice Dosage:35 mg/kg Administration:Intraperitoneal injection; 35 mg/kg; twice daily; 3 daysResult:Reduced average endometriotic implant size.
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SynonymsISO-1 | ISO 1 | ISO1 | MIF Antagonist
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PathwayOthers
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TargetOther Targets
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RecptorMIF
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Research AreaInflammation/Immunology
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Indication——
Chemical Information
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CAS Number478336-92-4
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Formula Weight235.2
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Molecular FormulaC12H13NO4
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Purity>98% (HPLC)
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SolubilityDMSO : ≥ 36 mg/mL; 153.04 mM
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SMILESCOC(=O)CC1CC(=NO1)c1ccc(O)cc1
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Chemical Name4,5-dihydro-3-(4-hydroxyphenyl)-5-isoxazoleacetic acid, methyl ester
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
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Syk Inhibitor II hyd...
The impact of spleen tyrosine kinase (Syk) signaling might be prominent in lupus because (i) Syk is a shared downstream signaling molecule among circulating immune complex, LPS, and (1→3)-β-D-glucan (BG), and (ii) all of these factors are detectable in the serum of Fc gamma receptor IIb-deficient (FcgRIIb-/-) mice with sepsis. Syk inhibition downregulated several inflammatory pathways in FcgRIIb-/- macrophages activated with BG + LPS suggesting the potential anti-inflammatory impact of Syk inhibitors in lupus.
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Acesulfame Potassium
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Conduritol A
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