Jervine( 11-Ketocyclopamine )

Catalog No. M17515 CAS No. 469-59-0

COA

Datasheet

HNMR

HPLC

MSDS

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Product Name

Jervine
Note

Research use only, not for human use.
Brief Description

The biological activity of Jervine is mediated via its interaction with the 7 passes transmembrane protein Smoothened. Jervine binds with and inhibits smoothened.
Description

The biological activity of Jervine is mediated via its interaction with the 7 passes transmembrane protein Smoothened. Jervine binds with and inhibits smoothened, which is an integral part of the Hedgehog signaling pathways. With smoothened inhibited, the GLI1 transcription cannot be activated and Hedgehog target genes cannot be transcribed.
In Vitro

Jervine (40 μM; 6, 12 and 24 hours) inhibits Akt phosphorylation. Jervine (40 μM; 2 hours) inhibits NF-jB activation decreased COX-2 overexpression and induced apoptosis. Western Blot Analysis Cell Line:HEL and TF1a cells Concentration:40 μM Incubation Time:6, 12 and 24 hours Result:Inhibited Akt phosphorylation.
In Vivo

Jervine (orally; 50-400 mg/kg) exerts 50.4-73.5% anti-inflammatory effects in carrageenan induced paw edema. Animal Model:Male Sprague Dawley rats (180-200? g)Dosage:50, 100, 200 and 400? mg/kg Administration:Orally Result:Exerted 50.4-73.5% anti-inflammatory effects in carrageenan induced paw edema.
Synonyms

11-Ketocyclopamine
Pathway

Others
Target

Other Targets
Recptor

Hedgehog| Smoothened
Research Area

Cancer
Indication

——

CAS Number

469-59-0
Formula Weight

425.61
Molecular Formula

C27H39NO3
Purity

>98% (HPLC)
Solubility

DMSO : 1 mg/mL2.35 mM;
SMILES

O=C1C2=C(C)[C@]3(CC[C@H]2[C@@H]2CC=C4C[C@H](CC[C@]4(C)[C@@H]12)O)O[C@@H]1C[C@@H](CN[C@H]1[C@H]3C)C
Chemical Name

——

1. Chen JK, et al. Genes Dev. 2002 Nov 1; 16(21): 2743–2748.

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