SU6656( SU6656 | SU 6656 | SU-6656 )

Catalog No. M17482 CAS No. 330161-87-0

COA

Datasheet

HNMR

HPLC

MSDS

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Product Name

SU6656
Note

Research use only, not for human use.
Brief Description

SU 6656 is a selective inhibitor of Src family kinases, with IC50 of 280 nM, 20 nM, 130 nM, and 170 nM for Src, Yes, Lyn, and Fyn, respectively.
Description

SU6656 is a potent and selective dual inhibitor of Src family kinases and Aurora kinase. SU6656 modulates CTGF (connective tissue growth factor) expression in an ERK-dependent manner. SU6656 induces caspase-independent cell death in FRO anaplastic thyroid carcinoma cells and therapeutic synergy in human synovial sarcoma growth, invasion and angiogenesis in vivo.
In Vitro

——
In Vivo

Animal Model:Swiss albino male mice Dosage:2, 4 mg/kg Administration:Intraperitoneal injection; once Result:Significantly decreased IPoCo mediated increase in fall down time.
Synonyms

SU6656 | SU 6656 | SU-6656
Pathway

MAPK/ERK Signaling
Target

Raf
Recptor

Fyn| Lyn| Src| Yes
Research Area

Cancer
Indication

——

CAS Number

330161-87-0
Formula Weight

371.45
Molecular Formula

C19H21N3O3S
Purity

>98% (HPLC)
Solubility

DMSO : 18.5 mg/mL. 49.80 mM;
SMILES

CN(C)S(=O)(=O)c1cc2c(cc1)NC(=O)/C/2=C\c1cc2c([nH]1)CCCC2
Chemical Name

(Z)-N,N-dimethyl-2-oxo-3-((4,5,6,7-tetrahydro-1H-indol-2-yl)methylene)indoline-5-sulfonamide

1. Blake RA, et al. Mol Cell Biol. 2000, 20(23), 9018-9027.

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