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Ro 67-7476
CAS No. 298690-60-5
Ro 67-7476( —— )
Catalog No. M17468 CAS No. 298690-60-5
Ro 67-7476 is a positive allosteric modulator of mGlu1 receptors. No activity at human mGlu1 receptors. Potentiates glutamate-induced calcium release with EC 50 of 60.1 nM.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 2MG | 39 | In Stock |
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| 5MG | 77 | In Stock |
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| 10MG | 120 | In Stock |
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| 25MG | 244 | In Stock |
|
| 50MG | 441 | In Stock |
|
| 100MG | 644 | In Stock |
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| 200MG | Get Quote | In Stock |
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| 500MG | Get Quote | In Stock |
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| 1G | Get Quote | In Stock |
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Biological Information
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Product NameRo 67-7476
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NoteResearch use only, not for human use.
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Brief DescriptionRo 67-7476 is a positive allosteric modulator of mGlu1 receptors. No activity at human mGlu1 receptors. Potentiates glutamate-induced calcium release with EC 50 of 60.1 nM.
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DescriptionRo 67-7476 is a positive allosteric modulator of mGlu1 receptors. No activity at human mGlu1 receptors. Potentiates glutamate-induced calcium release with EC 50 of 60.1 nM.
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In VitroIn the Purkinje cells of rat cerebellar slices, Ro 67-7476 increases the amplitude of mGluR1 excitatory postsynaptic potentials (EPSCs) evoked by 2,3-dihydroxy-6-nitro-7-sulfamoylbenzoquionxaline, picrotoxin, or AP5.?Ro 67-7476 activates ERK1/2 phosphorylation in the absence of exogenously added glutamate (EC50=163.3 nM). The EC50?value of? full P-ERK1/2 activation for Ro 67-7476 are nearly identical to the EC50 for calcium mobilization potentiation.Ro 67-7476 increases basal cAMP production approximately by 8%. It potentiated threshold responses to glutamate in the cAMP accumulation assay, with an EC50?value of 17.7 μM.
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In Vivo——
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Synonyms——
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PathwayEndocrinology/Hormones
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Target5-HT Receptor
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RecptormGluR1
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Research AreaNeurological Disease
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Indication——
Chemical Information
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CAS Number298690-60-5
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Formula Weight319.39
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Molecular FormulaC17H18FNO2S
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Purity>98% (HPLC)
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SolubilityDMSO : ≥ 40 mg/mL; 125.24 mM
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SMILESN1([C@@H](CCC1)c1ccc(cc1)F)S(=O)(=O)c1ccc(cc1)C
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Chemical Name——
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1.Hemstapat K et al. Mol Pharmacol. 2006 Aug, 70(2), 616-26
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