Home - Products - MAPK/ERK Signaling - Raf - SB408124

SB408124

CAS No. 288150-92-5

SB408124( —— )

Catalog No. M17465 CAS No. 288150-92-5

SB408124 is a non-peptide antagonist for OX1 receptor with Ki of 57 nM and 27 nM in both whole cell and membrane, respectively, exhibits 50-fold selectivity over OX2 receptor.

Purity : >98% (HPLC)

COA

Datasheet

HNMR

HPLC

MSDS

Handing Instructions

Size	Price / USD	Stock	Quantity
5MG	45	Get Quote
10MG	73	Get Quote
25MG	162	Get Quote
50MG	291	Get Quote
100MG	431	Get Quote
200MG	Get Quote	Get Quote
500MG	Get Quote	Get Quote
1G	Get Quote	Get Quote

Get Quotation Bulk Inquiry Add to Cart

Biological Information

Product Name

SB408124
Note

Research use only, not for human use.
Brief Description

SB408124 is a non-peptide antagonist for OX1 receptor with Ki of 57 nM and 27 nM in both whole cell and membrane, respectively, exhibits 50-fold selectivity over OX2 receptor.
Description

SB408124 is a non-peptide antagonist for OX1 receptor with Ki of 57 nM and 27 nM in both whole cell and membrane, respectively, exhibits 50-fold selectivity over OX2 receptor.
In Vitro

——
In Vivo

SB-408124 (30 μg/10 μl; i.c.v.; male Wistar rats) decreases Orexin-A induced water intake in Wistar rats.
Synonyms

——
Pathway

MAPK/ERK Signaling
Target

Raf
Recptor

OX1 (membrane)| OX1 (whole cell)
Research Area

Neurological Disease
Indication

——

Chemical Information

CAS Number

288150-92-5
Formula Weight

356.37
Molecular Formula

C19H18F2N4O
Purity

>98% (HPLC)
Solubility

DMSO : 50 mg/mL 140.30 mM; H2O : < 0.1 mg/mL
SMILES

CN(C)C1=CC=C(NC(=O)NC2=CC(C)=NC3=C(F)C=C(F)C=C23)C=C1
Chemical Name

——

Shipping & Storage Information

Storage

(-20℃)
Shipping

With Ice Pack
Stability

≥ 2 years

Reference

1. Langmead CJ, et al, Br J Pharmacol, 2004, 141(2) , 340-346.

Calculator

Molecular Weight Calculator

Dilution Calculator

Molarity Calculator

molnova catalog

related products

GNE-9815

GNE-9815 is a high kinase-selective inhibitor of RAF and targets KRAS-mutant cancers through combination therapy.
B-Raf IN 2

B-Raf IN 2, compound Ia, is a highly effective and specific inhibitor of BRAF. It exhibits significant potential for cancer research.
O4I2

O4I2 is an effective Oct3/4 inducer in various human cell lines including human fibroblasts.

Sign In Join Free