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SB408124

CAS No. 288150-92-5

SB408124( —— )

Catalog No. M17465 CAS No. 288150-92-5

SB408124 is a non-peptide antagonist for OX1 receptor with Ki of 57 nM and 27 nM in both whole cell and membrane, respectively, exhibits 50-fold selectivity over OX2 receptor.

Purity : >98% (HPLC)

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Size	Price / USD	Stock	Quantity
1 mL x 10 mM in DMSO	56	In Stock
5MG	38	In Stock
10MG	61	In Stock
25MG	121	In Stock
100MG	Get Quote	In Stock
200MG	Get Quote	In Stock
500MG	Get Quote	In Stock
1G	Get Quote	In Stock

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Biological Information

Product Name

SB408124
Note

Research use only, not for human use.
Brief Description

SB408124 is a non-peptide antagonist for OX1 receptor with Ki of 57 nM and 27 nM in both whole cell and membrane, respectively, exhibits 50-fold selectivity over OX2 receptor.
Description

SB408124 is a non-peptide antagonist for OX1 receptor with Ki of 57 nM and 27 nM in both whole cell and membrane, respectively, exhibits 50-fold selectivity over OX2 receptor.
In Vitro

——
In Vivo

SB-408124 (30 μg/10 μl; i.c.v.; male Wistar rats) decreases Orexin-A induced water intake in Wistar rats.
Synonyms

——
Pathway

MAPK/ERK Signaling
Target

Raf
Recptor

OX1 (membrane)| OX1 (whole cell)
Research Area

Neurological Disease
Indication

——

Chemical Information

CAS Number

288150-92-5
Formula Weight

356.37
Molecular Formula

C19H18F2N4O
Purity

>98% (HPLC)
Solubility

DMSO : 50 mg/mL 140.30 mM; H2O : < 0.1 mg/mL
SMILES

CN(C)C1=CC=C(NC(=O)NC2=CC(C)=NC3=C(F)C=C(F)C=C23)C=C1
Chemical Name

——

Shipping & Storage Information

Storage

(-20℃)
Shipping

With Ice Pack
Stability

≥ 2 years

Reference

1. Langmead CJ, et al, Br J Pharmacol, 2004, 141(2) , 340-346.

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