Cart
sales@molnova.com
Pardoprunox hydrochloride
CAS No. 269718-83-4
Pardoprunox hydrochloride( SLV-308 hydrochloride | DU-126891 hydrochloride )
Catalog No. M17462 CAS No. 269718-83-4
Pardoprunox hydrochloride is a novel partial dopamine D2 and D3 receptor agonist and serotonin 5-HT1A receptor agonist.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 2MG | 29 | In Stock |
|
| 5MG | 42 | In Stock |
|
| 10MG | 69 | In Stock |
|
| 25MG | 117 | In Stock |
|
| 50MG | 184 | In Stock |
|
| 100MG | 346 | In Stock |
|
| 200MG | Get Quote | In Stock |
|
| 500MG | Get Quote | In Stock |
|
| 1G | Get Quote | In Stock |
|
Biological Information
-
Product NamePardoprunox hydrochloride
-
NoteResearch use only, not for human use.
-
Brief DescriptionPardoprunox hydrochloride is a novel partial dopamine D2 and D3 receptor agonist and serotonin 5-HT1A receptor agonist.
-
DescriptionPardoprunox hydrochloride is a novel partial dopamine D2 and D3 receptor agonist and serotonin 5-HT1A receptor agonist, D2 (pKi = 8.1) and D3 receptor (pKi = 8.6) partial agonist and 5-HT1A receptor (pKi = 8.5) full agonist.(In Vitro):Pardoprunox (SLV-308) hydrochloride acts as a potent but partial D2 receptor agonist (pEC50= 8.0 and pA2=8.4) with an efficacy of 50% on forskolin stimulated cAMP accumulation. At human recombinant dopamine D3 receptors, Pardoprunox hydrochloride acts as a partial agonist in the induction of [(35)S]GTPgammaS binding (intrinsic activity of 67%; pEC50=9.2) and antagonized the dopamine induction of [(35)S]GTPgammaS binding (pA2=9.0). Pardoprunox hydrochloride acts as a full 5-HT1A receptor agonist on forskolin induced cAMP accumulation at cloned human 5-HT1A receptors but with low potency (pEC50=6.3).
-
In VitroPardoprunox (SLV-308) hydrochloride acts as a potent but partial D2 receptor agonist (pEC50= 8.0 and pA2=8.4) with an efficacy of 50% on forskolin stimulated cAMP accumulation. At human recombinant dopamine D3 receptors, Pardoprunox hydrochloride acts as a partial agonist in the induction of [(35)S]GTPgammaS binding (intrinsic activity of 67%; pEC50=9.2) and antagonized the dopamine induction of [(35)S]GTPgammaS binding (pA2=9.0). Pardoprunox hydrochloride acts as a full 5-HT1A receptor agonist on forskolin induced cAMP accumulation at cloned human 5-HT1A receptors but with low potency (pEC50=6.3).
-
In Vivo——
-
SynonymsSLV-308 hydrochloride | DU-126891 hydrochloride
-
PathwayMAPK/ERK Signaling
-
Targetp38 MAPK
-
Recptor5-HT1A| D2| D3
-
Research AreaNeurological Disease
-
Indication——
Chemical Information
-
CAS Number269718-83-4
-
Formula Weight269.73
-
Molecular FormulaC12H16ClN3O2
-
Purity>98% (HPLC)
-
SolubilityH2O : < 0.1 mg/mL
-
SMILESO=c1oc2c(N3CCN(C)CC3)cccc2[nH]1.Cl.Cl
-
Chemical Name——
Shipping & Storage Information
-
Storage(-20℃)
-
ShippingWith Ice Pack
-
Stability≥ 2 years
Reference
1.Glennon JC, et al.Synapse. 2006 Dec 15;60(8):599-608.
molnova catalog
related products
-
Asiatic acid
ActionsAsiatic acid is commonly used in wound healing. Asiatic acid has antioxidant,anti-inflammatory and neuroprotective properties.
-
CC-99677
CC-99677 (Gamcemetinib) is a selectively targeted covalent MAPKAPK2 (MK2) inhibitor for autoimmune diseases that translates biochemical potency into cellular potency as demonstrated by potent inhibition of heat shock protein 27 (HSP1) phosphorylation in LPS-activated monocyte THP-27 cells via a nucleophilic aromatic substitution (SNAr) mechanism.
-
PH797804
PH-797804 is a novel pyridinone inhibitor of p38α with IC50 of 26 nM in a cell-free assay; 4-fold more selective versus p38β and does not inhibit JNK2. Phase 2.
