Cart
sales@molnova.com
Home - Products - Angiogenesis - FGFR - EBE-A22

EBE-A22

CAS No. 229476-53-3

EBE-A22( EBE-A22 | EBE A22 | EBEA22 )

Catalog No. M17448 CAS No. 229476-53-3

EBE-A22 is a derivative of PD 153035 which can inhibit ErbB-1-phosphorylation, whereas EBE-A22 is inactive.

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
Size Price / USD Stock Quantity
2MG 49 In Stock
5MG 76 In Stock
10MG 106 In Stock
25MG 215 In Stock
50MG 327 In Stock
100MG 492 In Stock
500MG 1053 In Stock
1G Get Quote In Stock
Get Quotation Bulk Inquiry Add to Cart

Biological Information

  • Product Name
    EBE-A22
  • Note
    Research use only, not for human use.
  • Brief Description
    EBE-A22 is a derivative of PD 153035 which can inhibit ErbB-1-phosphorylation, whereas EBE-A22 is inactive.
  • Description
    EBE-A22 is a derivative of PD 153035. EBE-A22, has no effect on EGF-R TK but maintains a high cytotoxic profile. EBE-A22 binds to DNA and behave as typical intercalating agents. EBE-A22 unwinds supercoiled plasmid, stabilizes duplex DNA against heat denaturation, and produces negative CD and ELD signals, as expected for an intercalating agent. EBE-A22, but not PD153035, interacts preferentially with GC-rich sequences and discriminates against homooligomeric runs of A and T which are often cut more readily by the enzyme in the presence of the drug compared to the control.
  • In Vitro
    ——
  • In Vivo
    ——
  • Synonyms
    EBE-A22 | EBE A22 | EBEA22
  • Pathway
    Angiogenesis
  • Target
    FGFR
  • Recptor
    EGFR/ErbB1
  • Research Area
    Others-Field
  • Indication
    ——

Chemical Information

  • CAS Number
    229476-53-3
  • Formula Weight
    374.23
  • Molecular Formula
    C17H16BrN3O2
  • Purity
    >98% (HPLC)
  • Solubility
    DMSO : 50 mg/mL 133.61 mM; H2O : < 0.1 mg/mL
  • SMILES
    CN(c1cc(ccc1)Br)c1ncnc2cc(c(cc12)OC)OC
  • Chemical Name
    N-(3-bromophenyl)-6,7-dimethoxy-N-methylquinazolin-4-amine

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1. Goossens JF, et al. DNA interaction of the tyrosine protein kinase inhibitor PD153035 and its N-methyl analogue. Biochemistry. 2001 Apr 17;40(15):4663-71.
Calculator

Molecular Weight Calculator

Dilution Calculator

Molarity Calculator

molnova catalog
related products

  • Aprutumab

    Aprutumab (BAY 1179470) is a human FGFR2 monoclonal antibody with affinity to FGFR2 isoforms FGFR2-IIIB and FGFR2-IIIC. Aprutumab is commonly used to synthesize antibody-drug conjugates.

  • H3B-6527

    A potent, highly selective covalent FGFR4 inhibitor with IC50 of <1.2 nM.

  • FGF-401

    FGF-401 (NVP-FGF401, Roblitinib, FGF401)?is a first-in-class, potent, highly selective FGFR4 inhibitor with IC50 of 1.1 nM.

Sign In Join Free